Ferroptosis is a non-apoptotic cell death mechanism characterized by iron-dependent
membrane lipid peroxidation. Here, we review what is known about the cellular mechanisms …

Background The global rise of metabolic disorders, such as obesity, type 2 diabetes, and
cardiovascular disease, demands a thorough molecular understanding of the cellular …

Ferroptosis is a form of programmed cell death characterized by intracellular iron
accumulation and lipid peroxidation, and earlier studies identified glutathione peroxidase 4 …

Gene knock outs (KOs) are efficiently engineered through CRISPR–Cas9-induced frameshift
mutations. While the efficiency of DNA editing is readily verified by DNA sequencing, a …

Ferroptosis is an oxidative form of nonapoptotic cell death whose transcriptional regulation
is poorly understood. Cap'n'collar (CNC) transcription factors including nuclear factor …

Cell death can be executed by regulated apoptotic and nonapoptotic pathways, including
the iron-dependent process of ferroptosis. Small molecules are essential tools for studying …

The ubiquitin–proteasome system (UPS) is the major intracellular and non-lysosomal
protein degradation system. Thanks to its unique capacity of eliminating old, damaged …

The majority of critically ill intensive care unit (ICU) patients with severe sepsis develop ICU-
acquired weakness (ICUAW) characterized by loss of muscle mass, reduction in myofiber …

Nrf1 is a member of the nuclear erythroid 2-like family of transcription factors that regulate
stress-responsive gene expression in animals. Newly synthesized Nrf1 is targeted to the …

Abstract Purpose: How exosomal RNAs released within the bone marrow microenvironment
affect proteasome inhibitors'(PI) sensitivity of multiple myeloma is currently unknown. This …