Transcription factors of the NFAT family: regulation and function
A Rao, C Luo, PG Hogan - Annual review of immunology, 1997 - annualreviews.org
▪ Abstract As targets for the immunosuppressive drugs cyclosporin A and FK506,
transcription factors of the NFAT (nuclear factor of activated T cells) family have been the …
transcription factors of the NFAT (nuclear factor of activated T cells) family have been the …
Partners in transcription: NFAT and AP-1
Combinatorial regulation is a powerful mechanism that enables tight control of gene
expression, via integration of multiple signaling pathways that induce different transcription …
expression, via integration of multiple signaling pathways that induce different transcription …
[HTML][HTML] NFAT control of immune function: New Frontiers for an Abiding Trooper
Nuclear factor of activated T cells (NFAT) was first described almost three decades ago as a
Ca 2+/calcineurin-regulated transcription factor in T cells. Since then, a large body of …
Ca 2+/calcineurin-regulated transcription factor in T cells. Since then, a large body of …
Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3
CR Beals, CM Sheridan, CW Turck, P Gardner… - Science, 1997 - science.org
The transcription factor NF-AT responds to Ca2+-calcineurin signals by translocating to the
nucleus, where it participates in the activation of early immune response genes. Calcineurin …
nucleus, where it participates in the activation of early immune response genes. Calcineurin …
Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A
The flow of information from calcium-mobilizing receptors to nuclear factor of activated T
cells (NFAT)–dependent genes is critically dependent on interaction between the …
cells (NFAT)–dependent genes is critically dependent on interaction between the …
Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA
The nuclear factor of activated T cells (NFAT) and the AP-1 heterodimer, Fos–Jun,
cooperatively bind a composite DNA site and synergistically activate the expression of many …
cooperatively bind a composite DNA site and synergistically activate the expression of many …
[HTML][HTML] Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity
H Okamura, J Aramburu, C García-Rodríguez… - Molecular cell, 2000 - cell.com
NFAT transcription factors are highly phosphorylated proteins that are regulated by the
calcium-dependent phosphatase calcineurin. We show by mass spectrometry that NFAT1 is …
calcium-dependent phosphatase calcineurin. We show by mass spectrometry that NFAT1 is …
NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun
C López-Rodríguez, J Aramburu… - Proceedings of the …, 1999 - National Acad Sciences
NFAT transcription factors are related to NF-κB/Rel proteins and form cooperative
complexes with Fos and Jun on DNA. We have identified an NFAT-related protein, NFAT5 …
complexes with Fos and Jun on DNA. We have identified an NFAT-related protein, NFAT5 …
Regulation of interleukin-8 gene expression
KA Roebuck - Journal of interferon & cytokine research, 1999 - liebertpub.com
Interleukin-8 (IL-8), a member of the CXC chemokine family, is an important activator and
chemoattractant for neutrophils and has been implicated in a variety of inflammatory …
chemoattractant for neutrophils and has been implicated in a variety of inflammatory …
Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction.
CR Beals, NA Clipstone, SN Ho… - Genes & …, 1997 - genesdev.cshlp.org
The NF-AT family of transcription factors participates in the regulation of early immune
response genes such as IL-2, IL-4, CD40 ligand, and Fas ligand in response to …
response genes such as IL-2, IL-4, CD40 ligand, and Fas ligand in response to …