Cholesterol homeostasis is vital for proper cellular and systemic functions. Disturbed
cholesterol balance underlies not only cardiovascular disease but also an increasing …

Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes degradation of low-density
lipoprotein receptor (LDLR) and plays a central role in regulating plasma levels of LDL …

910 levels, whereas PCSK9 overexpression did not cause an increase in plasma lipids but
in atherosclerotic lesion size18, 19). The Atheroma IVUS study revealed that the necrotic …

Since the discovery of the role of proprotein convertase subtilisin kexin 9 (PCSK9) in the
regulation of low-density lipoprotein cholesterol (LDL-C) in 2003, a paradigm shift in the …

Regulation of pro-protein convertase subtilisin/kexin type 9 (PCSK9) by drugs has led to the
development of a still small number of agents with powerful activity on low-density …

Hyperlipidemia is a common metabolic disorder with high morbidity and mortality, which
brings heavy burden on social. Understanding its pathogenesis and finding its potential …

Abstract Purpose of Review Non-coding RNAs (ncRNAs) including microRNAs (miRNAs)
and circular RNAs (circRNAs) are pivotal regulators of mRNA and protein expression that …

Proprotein convertase subtilisin/kexin type 9 (PCSK9) affects cholesterol homeostasis by
targeting hepatic LDL receptor (LDLR) for lysosomal degradation. Clinically, PCSK9 …

Simple Summary Hepatocellular carcinoma (HCC) is the fifth leading and highly aggressive
lethal liver cancer. The most common cause of HCC is liver cirrhosis because of multiple …

Non-alcoholic fatty liver disease (NAFLD) is becoming the main cause of liver disease in
Western countries, especially in morbidly obese patients (MOPs). The proprotein convertase …