Sulfonyl fluorides as targets and substrates in the development of new synthetic methods

TSB Lou, MC Willis - Nature Reviews Chemistry, 2022 - nature.com
The advent of sulfur (vi)-fluoride exchange (SuFEx) processes as transformations with click-
like reactivity has invigorated research into electrophilic species featuring a sulfur–fluorine …

The growing applications of SuFEx click chemistry

AS Barrow, CJ Smedley, Q Zheng, S Li… - Chemical Society …, 2019 - pubs.rsc.org
SuFEx (Sulfur Fluoride Exchange) is a modular, next generation family of click reactions,
geared towards the rapid and reliable assembly of functional molecules. This review …

Advances in the construction of diverse SuFEx linkers

D Zeng, WP Deng, X Jiang - National Science Review, 2023 - academic.oup.com
Sulfur fluoride exchange (SuFEx), a new generation of click chemistry, was first presented by
Sharpless, Dong and co-workers in 2014. Owing to the high stability and yet efficient …

Sulfur fluoride exchange

JA Homer, L Xu, N Kayambu, Q Zheng… - Nature Reviews …, 2023 - nature.com
Click chemistry is a conceptual strategy to rapidly synthesize and discover functional
molecules. Sulfur fluoride exchange (SuFEx) is a click reaction that has revolutionized …

SuFExable polymers with helical structures derived from thionyl tetrafluoride

S Li, G Li, B Gao, SP Pujari, X Chen, H Kim, F Zhou… - Nature …, 2021 - nature.com
Sulfur (vi) fluoride exchange (SuFEx) is a category of click chemistry that enables covalent
linking of modular units through sulfur (vi) connective hubs. The efficiency of SuFEx and the …

Synthesis of chiral sulfonimidoyl chloride via desymmetrizing enantioselective hydrolysis

G Yang, Y Yuan, Y Tian, S Zhang, X Cui… - Journal of the …, 2023 - ACS Publications
Direct construction of chiral S (VI) from prochiral S (II) is a formidable challenge due to the
inevitable formation of stable chiral S (IV). Previous synthetic strategies rely on the …

SuFEx click chemistry enabled late-stage drug functionalization

Z Liu, J Li, S Li, G Li, KB Sharpless… - Journal of the American …, 2018 - ACS Publications
Sulfur (VI) Fluoride Exchange (SuFEx) is a new family of click chemistry transformations
which relies on readily available materials to produce compounds bearing the SVI–F motif …

Selective fluorosulfonylation of thianthrenium salts enabled by electrochemistry

X Kong, Y Chen, Q Liu, WJ Wang, S Zhang… - Organic …, 2023 - ACS Publications
A practical electrochemically driven method for fluorosulfonylation of both aryl and alkyl
thianthrenium salts has been disclosed. The strategy does not need external redox reagents …

Using sulfuramidimidoyl fluorides that undergo sulfur(vi) fluoride exchange for inverse drug discovery

GJ Brighty, RC Botham, S Li, L Nelson… - Nature …, 2020 - nature.com
Drug candidates that form covalent linkages with their target proteins have been
underexplored compared with the conventional counterparts that modulate biological …

Divergent sulfur (VI) fluoride exchange linkage of sulfonimidoyl fluorides and alkynes

D Zeng, Y Ma, WP Deng, M Wang, X Jiang - Nature Synthesis, 2022 - nature.com
Sulfur (VI) fluoride exchange reactions have been applied to the linkage of a diverse range
of molecules. However, the connectivity of fluorosulfuryls with alkynes remains a formidable …