Bronchopulmonary C-fibers and a subset of mechanically sensitive, acid-sensitive
myelinated sensory nerves play essential roles in regulating cough. These vagal sensory …

Opioid-induced respiratory depression (OIRD) represents the primary cause of death
associated with therapeutic and recreational opioid use. Within the United States, the rate of …

Excessive coughing is one of the most common reasons for seeking medical advice, yet the
available therapies for treating cough disorders are inadequate. Humans can voluntarily …

Rationale: Coughing in humans is typically preceded by a desire (or urge) to cough. The
neural circuitry involved in sensing airway irritation and generating the urge-to-cough in …

This review of the central nervous control systems for voice and swallowing has suggested
that the traditional concepts of a separation between cortical and limbic and brain stem …

Delineation of neural mechanisms involved in reflex cough is essential for understanding its
many physiological and clinical complexities, and the development of more desirable …

Airway protections is the prevention and/or removal of material by behaviors such as cough
and swallow. We hypothesized these behaviors are coordinated to respond to aspiration …

Computational models of the neural control system for breathing in mammals provide a
theoretical and computational framework bringing together experimental data obtained from …

Cough and breathing are generated by a common muscular system. However, these two
behaviors differ significantly in their mechanical features and regulation. The current …

There is an overwhelming body of evidence to support the existence of higher brain
circuitries involved in the sensory detection of airways irritation and the motor control of …