Cancer therapies, including conventional chemotherapy, radiation, and molecularly targeted
agents, can lead to tumor eradication through a variety of mechanisms. In addition to their …

Mitochondria are crucial cellular organelles. Under extracellular stimulations, mitochondria
undergo constant fusion and fission dynamics to meet different cellular demands …

Allogeneic hematopoietic stem cell transplantation is a definitive therapy for a variety of
disorders. One of the complications is acute graft-versus-host disease (aGVHD), which has a …

Allogeneic stem cell transplantation (allo-SCT) is a curable method for the treatment of
hematological malignancies. In the past two decades, the establishment of haploidentical …

Allogeneic hematopoietic stem cell transplantation (allo-HCT) is a potentially curative
therapy for patients suffering from hematological malignancies via the donor immune system …

Despite the increasing use of humanized mouse models to study new approaches of graft-
versus-host disease (GVHD) prevention, the pathogenesis of xenogeneic GVHD (xGVHD) in …

Mesenchymal stromal cells (MSCs) have potent immunomodulatory properties that make
them an attractive tool against graft-vs.-host disease (GVHD). However, despite promising …

Janus kinase 2 (JAK2) signal transduction is a critical mediator of the immune response.
JAK2 is implicated in the onset of graft-versus-host disease (GVHD), which is a significant …

Allogeneic hematopoietic cell transplantation is a potentially curative therapy for many
malignant and nonmalignant hematologic diseases. Graft-versus-host disease (GVHD) is a …

Graft-versus-host disease (GVHD) remains an important cause of morbidity and mortality
after allogeneic hematopoietic cell transplantation (allo-HCT). For decades, GVHD …