Epstein–Barr virus latent genes

MS Kang, E Kieff - Experimental & molecular medicine, 2015 - nature.com
Abstract Latent Epstein–Barr virus (EBV) infection has a substantial role in causing many
human disorders. The persistence of these viral genomes in all malignant cells, yet with the …

The role of Epstein–Barr virus in epithelial malignancies

SW Tsao, CM Tsang, KF To, KW Lo - The Journal of pathology, 2015 - Wiley Online Library
The close association of Epstein–Barr virus (EBV) infection with non‐keratinizing
nasopharyngeal carcinomas and a subset of gastric carcinomas suggests that EBV infection …

Epstein-Barr virus infections: biology, pathogenesis, and management

SE Straus, JI Cohen, G Tosato… - Annals of internal medicine, 1993 - acpjournals.org
Epstein-Barr virus (EBV) encodes genes that ensure its persistence in human B
lymphocytes. Some of the genes encourage B-cell proliferation; others are poised to evade …

Cell-to-cell contact as an efficient mode of Epstein-Barr virus infection of diverse human epithelial cells

S Imai, JUN Nishikawa, K Takada - Journal of virology, 1998 - Am Soc Microbiol
We show clear evidence for direct infection of various human epithelial cells by Epstein-Barr
virus (EBV) in vitro. The successful infection was achieved by using recombinant EBV (Akata …

Three pathways of Epstein-Barr virus gene activation from EBNA1-positive latency in B lymphocytes

M Rowe, AL Lear, D Croom-Carter, AH Davies… - Journal of …, 1992 - Am Soc Microbiol
Previous studies on Epstein-Barr virus (EBV)-positive B-cell lines have identified two distinct
forms of virus latency. Lymphoblastoid cell lines generated by virus-induced transformation …

Immediate early and early lytic cycle proteins are frequent targets of the Epstein-Barr virus–induced cytotoxic T cell response

NM Steven, NE Annels, A Kumar, AM Leese… - The Journal of …, 1997 - rupress.org
Epstein-Barr virus (EBV), a human γ-herpesvirus, can establish both nonproductive (latent)
and productive (lytic) infections. Although the CD8+ cytotoxic T lymphocyte (CTL) response …

Nitric oxide produced by human B lymphocytes inhibits apoptosis and Epstein-Barr virus reactivation

JB Mannick, K Asano, K Izumi, E Kieff, JS Stamler - Cell, 1994 - cell.com
Nitric oxide (NO) produced by murine macrophages is important in murine resistance to
ectromelia virus, herpes simplex virus, and vaccinia virus infection. In contrast, NO …

Pathogenic roles for Epstein–Barr virus (EBV) gene products in EBV-associated proliferative disorders

JM Middeldorp, AATP Brink, AJC Van den Brule… - Critical reviews in …, 2003 - Elsevier
Epstein–Barr virus (EBV) is associated with a still growing spectrum of clinical disorders,
ranging from acute and chronic inflammatory diseases to lymphoid and epithelial …

The immunoreceptor tyrosine-based activation motif of Epstein–Barr virus LMP2A is essential for blocking BCR-mediated signal transduction

S Fruehling, R Longnecker - Virology, 1997 - Elsevier
The Epstein–Barr virus (EBV) latent membrane protein 2A (LMP2A) blocks B-cell receptor
(BCR) signal transduction in EBV-immortalized B lymphocytesin vitro. The cytoplasmic …

An integral membrane protein (LMP2) blocks reactivation of Epstein-Barr virus from latency following surface immunoglobulin crosslinking.

CL Miller, JH Lee, E Kieff… - Proceedings of the …, 1994 - National Acad Sciences
The role of latent membrane protein 2 (LMP2) in Epstein-Barr virus (EBV) infection was
evaluated by using latently infected primary B lymphocytes that had been growth …