Aurora kinase A (AURKA) belongs to the family of serine/threonine kinases, whose
activation is necessary for cell division processes via regulation of mitosis. AURKA shows …

Computer-aided drug discovery/design methods have played a major role in the
development of therapeutically important small molecules for over three decades. These …

In the relatively young but expanding field of irreversible kinase inhibitor drug discovery,
there are two main developments that are of central importance. First, the patients have …

Despite significant improvements of new treatment options, cancer continues to represent as
one of the most common and fatal disease. The EGFR signaling pathway is considered as a …

Introducing novel strategies, concepts, and technologies that speed up drug discovery and
the drug development cycle is of great importance both in the highly competitive …

Aurora kinase belongs to serine/threonine kinase family which controls cell division.
Therapeutic inhibition of Aurora kinase showed great promise as probable anticancer …

Pyrimidine ring and its fused derivatives including pyrazolo [3, 4-d] pyrimidine, pyrido [2, 3-d]
pyrimidine, quinazoline, and furo [2, 3-d] pyrimidine compounds had received much interest …

We present a fast and effective covalent docking approach suitable for large-scale virtual
screening (VS). We applied this method to four targets (HCV NS3 protease, Cathepsin K …

The Asp-Phe-Gly (DFG) motif plays an important role in the regulation of kinase activity.
Structure-based drug design was performed to design compounds able to interact with the …

The EGFRT790M mutant contributes approximately 50% to clinically acquired resistance
against gefitinib or erlotinib. However, almost all the single agent clinical trials of the second …