Mycobacterium tuberculosis (Mtb) is an extremely successful intracellular pathogen that
causes tuberculosis (TB), which remains the leading infectious cause of human death. The …

Tuberculosis (TB) caused by the bacterial pathogen Mycobacterium tuberculosis (Mtb)
remains one of the deadliest infectious diseases with over a billion deaths in the past 200 …

Mycobacterium tuberculosis and Mycobacterium marinum are thought to exert virulence, in
part, through their ability to lyse host cell membranes. The type VII secretion system ESX-1 [6 …

The study of host–pathogen interactions has illuminated fundamental research avenues in
both infection and cell biology. Zebrafish (Danio rerio) larvae are genetically tractable …

Acidic pH arrests the growth of Mycobacterium tuberculosis in vitro (pH< 5.8) and is thought
to significantly contribute to the ability of macrophages to control M. tuberculosis replication …

To be effective, chemotherapy against tuberculosis (TB) must kill the intracellular population
of the pathogen, Mycobacterium tuberculosis. However, how host cell microenvironments …

Necrosis of macrophages in the granuloma, the hallmark immunological structure of
tuberculosis, is a major pathogenic event that increases host susceptibility. Through a …

The capacity of Mycobacterium tuberculosis (Mtb) to tolerate multiple antibiotics represents a
major problem in tuberculosis (TB) management. Heterogeneity in Mtb populations is one of …

Mycobacterium tuberculosis (Mtb) senses and adapts to acidic host environments during the
course of pathogenesis. Mutants defective in acidic pH-dependent adaptations are often …

Mycobacterium tuberculosis and its close relative Mycobacterium marinum infect
macrophages and induce the formation of granulomas, organized macrophage-rich immune …