Macrophages are increasingly recognized as essential players in the maintenance of
intestinal homeostasis and as key sentinels of the intestinal immune system. However …

Diversity and plasticity are hallmarks of cells of the monocyte-macrophage lineage. In
response to IFNs, Toll-like receptor engagement, or IL-4/IL-13 signaling, macrophages …

Macrophages, which are functional plasticity cells, have the ability to phagocytize and digest
foreign substances and acquire pro-(M1-like) or anti-inflammatory (M2-like) phenotypes …

The intestine contains the largest pool of macrophages in the body which are essential for
maintaining mucosal homeostasis in the face of the microbiota and the constant need for …

Ly6C hi monocytes seed the healthy intestinal lamina propria to give rise to resident CX 3
CR1+ macrophages that contribute to the maintenance of gut homeostasis. Here we report …

Eosinophils can regulate local immune and inflammatory responses, and their accumulation
in the blood and tissue is associated with several inflammatory and infectious diseases …

The microbiota stimulates inflammation, but the signaling pathways and the members of the
microbiota involved remain poorly understood. We found that the microbiota induces …

Inflammatory monocyte-derived effector cells play an important role in the pathogenesis of
numerous inflammatory diseases. However, no treatment option exists that is capable of …

Eosinophils are typically considered to be specialized effector cells that are recruited to the
tissues as a result of T helper type 2 (Th2) cell responses associated with helminth infections …

The intestinal lamina propria (LP) contains a diverse array of mononuclear phagocyte (MNP)
subsets, including conventional dendritic cells (cDC), monocytes and tissue-resident …