[HTML][HTML] Advances in pluripotent stem cells: history, mechanisms, technologies, and applications
G Liu, BT David, M Trawczynski, RG Fessler - Stem cell reviews and …, 2020 - Springer
Over the past 20 years, and particularly in the last decade, significant developmental
milestones have driven basic, translational, and clinical advances in the field of stem cell …
milestones have driven basic, translational, and clinical advances in the field of stem cell …
[HTML][HTML] Common stemness regulators of embryonic and cancer stem cells
C Hadjimichael, K Chanoumidou… - World journal of stem …, 2015 - ncbi.nlm.nih.gov
Pluripotency of embryonic stem cells (ESCs) and induced pluripotent stem cells is regulated
by a well characterized gene transcription circuitry. The circuitry is assembled by ESC …
by a well characterized gene transcription circuitry. The circuitry is assembled by ESC …
YAP/TAZ activity in stromal cells prevents ageing by controlling cGAS–STING
HL Sladitschek-Martens, A Guarnieri, G Brumana… - Nature, 2022 - nature.com
Ageing is intimately connected to the induction of cell senescence,, but why this is so
remains poorly understood. A key challenge is the identification of pathways that normally …
remains poorly understood. A key challenge is the identification of pathways that normally …
[HTML][HTML] Rapid single-step induction of functional neurons from human pluripotent stem cells
Available methods for differentiating human embryonic stem cells (ESCs) and induced
pluripotent cells (iPSCs) into neurons are often cumbersome, slow, and variable …
pluripotent cells (iPSCs) into neurons are often cumbersome, slow, and variable …
Generation of pure GABAergic neurons by transcription factor programming
Approaches to differentiating pluripotent stem cells (PSCs) into neurons currently face two
major challenges—(i) generated cells are immature, with limited functional properties; and …
major challenges—(i) generated cells are immature, with limited functional properties; and …
Chemically defined conditions for human iPSC derivation and culture
We re-examine the individual components for human embryonic stem cell (ESC) and
induced pluripotent stem cell (iPSC) culture and formulate a cell culture system in which all …
induced pluripotent stem cell (iPSC) culture and formulate a cell culture system in which all …
[HTML][HTML] A retinoic acid-enhanced, multicellular human blood-brain barrier model derived from stem cell sources
Blood-brain barrier (BBB) models are often used to investigate BBB function and screen
brain-penetrating therapeutics, but it has been difficult to construct a human model that …
brain-penetrating therapeutics, but it has been difficult to construct a human model that …
Single luminal epithelial progenitors can generate prostate organoids in culture
The intrinsic ability to exhibit self-organizing morphogenetic properties in ex vivo culture may
represent a general property of tissue stem cells. Here we show that single luminal …
represent a general property of tissue stem cells. Here we show that single luminal …
Induction of human neuronal cells by defined transcription factors
Somatic cell nuclear transfer, cell fusion, or expression of lineage-specific factors have been
shown to induce cell-fate changes in diverse somatic cell types,,,,,,,,,,,. We recently observed …
shown to induce cell-fate changes in diverse somatic cell types,,,,,,,,,,,. We recently observed …
[HTML][HTML] A review of protocols for human iPSC culture, cardiac differentiation, subtype-specification, maturation, and direct reprogramming
The methods for the culture and cardiomyocyte differentiation of human embryonic stem
cells, and later human induced pluripotent stem cells (hiPSC), have moved from a complex …
cells, and later human induced pluripotent stem cells (hiPSC), have moved from a complex …