The leukaemia stem cell: similarities, differences and clinical prospects in CML and AML
For two decades, leukaemia stem cells (LSCs) in chronic myeloid leukaemia (CML) and
acute myeloid leukaemia (AML) have been advanced paradigms for the cancer stem cell …
acute myeloid leukaemia (AML) have been advanced paradigms for the cancer stem cell …
[HTML][HTML] The CD70-CD27 axis in oncology: the new kids on the block
T Flieswasser, A Van den Eynde… - Journal of experimental …, 2022 - Springer
The immune checkpoint molecule CD70 and its receptor CD27 are aberrantly expressed in
many hematological and solid malignancies. Dysregulation of the CD70-CD27 axis within …
many hematological and solid malignancies. Dysregulation of the CD70-CD27 axis within …
Functions of immune checkpoint molecules beyond immune evasion
Y Zhang, J Zheng - Regulation of cancer immune checkpoints: molecular …, 2020 - Springer
Immune checkpoint molecules, including inhibitory and stimulatory immune checkpoint
molecules, are defined as ligand–receptor pairs that exert inhibitory or stimulatory effects on …
molecules, are defined as ligand–receptor pairs that exert inhibitory or stimulatory effects on …
The Wnt signaling pathway in cancer
Y Duchartre, YM Kim, M Kahn - Critical reviews in oncology/hematology, 2016 - Elsevier
The Wnt signaling pathway is critically involved in both the development and homeostasis of
tissues via regulation of their endogenous stem cells. Aberrant Wnt signaling has been …
tissues via regulation of their endogenous stem cells. Aberrant Wnt signaling has been …
The chronic myeloid leukemia stem cell: stemming the tide of persistence
TL Holyoake, D Vetrie - Blood, The Journal of the American …, 2017 - ashpublications.org
Chronic myeloid leukemia (CML) is caused by the acquisition of the tyrosine kinase BCR-
ABL1 in a hemopoietic stem cell, transforming it into a leukemic stem cell (LSC) that self …
ABL1 in a hemopoietic stem cell, transforming it into a leukemic stem cell (LSC) that self …
[HTML][HTML] Cancer stem cells—key players in tumor relapse
M Marzagalli, F Fontana, M Raimondi, P Limonta - Cancers, 2021 - mdpi.com
Simple Summary Cancer is one of the hardest pathologies to fight, being one of the main
causes of death worldwide despite the constant development of novel therapeutic strategies …
causes of death worldwide despite the constant development of novel therapeutic strategies …
[HTML][HTML] Chronic myeloid leukemia stem cells
Chronic myeloid leukemia (CML) is caused by BCRABL1 in a cell with the biological
potential, intrinsic or acquired, to cause leukemia. This cell is commonly termed the CML …
potential, intrinsic or acquired, to cause leukemia. This cell is commonly termed the CML …
[HTML][HTML] Immune checkpoint blockade and CAR-T cell therapy in hematologic malignancies
H Wang, G Kaur, AI Sankin, F Chen, F Guan… - Journal of hematology & …, 2019 - Springer
Harnessing the power of the immune system to recognize and eliminate cancer cells is a
longtime exploration. In the past decade, monoclonal antibody (mAb)-based immune …
longtime exploration. In the past decade, monoclonal antibody (mAb)-based immune …
[HTML][HTML] MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer
T Zhan, G Ambrosi, AM Wandmacher… - Nature …, 2019 - nature.com
In colorectal cancer (CRC), aberrant Wnt signalling is essential for tumorigenesis and
maintenance of cancer stem cells. However, how other oncogenic pathways converge on …
maintenance of cancer stem cells. However, how other oncogenic pathways converge on …
[HTML][HTML] Chronic myeloid leukemia stem cells: targeting therapeutic implications
Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasm driven by BCR-
ABL1 oncoprotein, which plays a pivotal role in CML pathology, diagnosis, and treatment as …
ABL1 oncoprotein, which plays a pivotal role in CML pathology, diagnosis, and treatment as …