Gene therapy encompasses the transfer of exogenous genetic materials into the patient's
target cells to treat or prevent diseases. Nevertheless, the transfer of genetic material into …

Beamline I22 at Diamond Light Source is dedicated to the study of soft-matter systems from
both biological and materials science. The beamline can operate in the range 3.7 keV to 22 …

There have been numerous advancements in the early diagnosis, detection, and treatment
of genetic diseases. In this regard, CRISPR technology is promising to treat some types of …

Abstract Evaluation of the effect of different parameters for designing a non-viral vector in
gene delivery systems has great importance. In this manner, 2D crystals, precisely layered …

The standard-of-care chemotherapy is important in the treatment of osteosarcoma and bone
metastastic tumors. However, the efficacy is limited by the specific physiological environment …

Self-microemulsifying drug-delivery system (SMEDDS) can be defined as an isotropic
system containing lipid and surfactant as well as cosurfactant that develop an emulsion in …

Objective The roll-out of the Pfizer-BioNTech BNT162b2 COVID-19 vaccine has brought
many logistical challenges, such as the absence of comprehensive stability data leading to …

A chitosan derivative (Pyr-CS-HTAP) having pyrene (Pyr) and N-[(2-hydroxyl-3-
trimethylammonium)] propyl (HTAP) units conjugated at C6 and C2 positions, respectively …

Lipopolyplexes (LPDs) are of considerable interest for use as gene delivery vehicles. Here
LPDs have been prepared from cationic vesicles (composed of a 1: 1 molar ratio of DOTMA …

Cationic liposomes have shown great potential in efficient siRNA delivery, and their positive
charge is crucial for tight extracellular siRNA binding, effective intracellular siRNA …