Cannabinoids and pain: sites and mechanisms of action
K Starowicz, DP Finn - Advances in Pharmacology, 2017 - Elsevier
The endocannabinoid system, consisting of the cannabinoid 1 receptor (CB 1 R) and
cannabinoid 2 receptor (CB 2 R), endogenous cannabinoid ligands (endocannabinoids) …
cannabinoid 2 receptor (CB 2 R), endogenous cannabinoid ligands (endocannabinoids) …
Major phytocannabinoids and their related compounds: should we only search for drugs that act on cannabinoid receptors?
The most important discoveries in pharmacology, such as certain classes of analgesics or
chemotherapeutics, started from natural extracts which have been found to have effects in …
chemotherapeutics, started from natural extracts which have been found to have effects in …
A critical role for prefrontocortical endocannabinoid signaling in the regulation of stress and emotional behavior
RJ McLaughlin, MN Hill, BB Gorzalka - Neuroscience & Biobehavioral …, 2014 - Elsevier
The prefrontal cortex (PFC) provides executive control of the brain in humans and rodents,
coordinating cognitive, emotional, and behavioral responses to threatening stimuli and …
coordinating cognitive, emotional, and behavioral responses to threatening stimuli and …
Cannabidiol in the prelimbic cortex modulates the comorbid condition between the chronic neuropathic pain and depression-like behaviour in rats: The role of medial …
RB Malvestio, P Medeiros, SE Negrini-Ferrari… - Brain Research …, 2021 - Elsevier
The prelimbic division (PrL) of the medial prefrontal cortex (mPFC) is a cerebral division that
is putatively implicated in the chronic pain and depression. We investigated the activity of …
is putatively implicated in the chronic pain and depression. We investigated the activity of …
Characterization of the sensory, affective, cognitive, biochemical, and neuronal alterations in a modified chronic constriction injury model of neuropathic pain in mice
P Medeiros, RL de Freitas, S Boccella… - Journal of …, 2020 - Wiley Online Library
The chronic constriction injury (CCI) of the sciatic nerve is a nerve injury‐based model of
neuropathic pain (NP). Comorbidities of NP such as depression, anxiety, and cognitive …
neuropathic pain (NP). Comorbidities of NP such as depression, anxiety, and cognitive …
The medial prefrontal regulation of maternal behavior across postpartum: A triadic model.
M Li - Psychological review, 2023 - psycnet.apa.org
Maternal behavior is a highly motivated and adaptive social behavior. Its frequency and
pattern change across the postpartum period in response to the changing characteristics of …
pattern change across the postpartum period in response to the changing characteristics of …
N-methyl-d-aspartate Receptors in the Prelimbic Cortex are Critical for the Maintenance of Neuropathic Pain
P Medeiros, SE Negrini-Ferrari, E Palazzo… - Neurochemical …, 2019 - Springer
The mechanisms underlying chronic and neuropathic pain pathology involve peripheral and
central sensitisation. The medial prefrontal cortex (mPFC) seems to participate in pain …
central sensitisation. The medial prefrontal cortex (mPFC) seems to participate in pain …
An adapted chronic constriction injury of the sciatic nerve produces sensory, affective, and cognitive impairments: a peripheral mononeuropathy model for the study of …
P Medeiros, IR Dos Santos, IM Júnior, E Palazzo… - Pain …, 2021 - academic.oup.com
Background Chronic constriction injury (CCI) is a model of neuropathic pain induced by four
loose ligatures around the sciatic nerve. This work aimed to investigate the sensory …
loose ligatures around the sciatic nerve. This work aimed to investigate the sensory …
Relevance of dorsomedial hypothalamus, dorsomedial division of the ventromedial hypothalamus and the dorsal periaqueductal gray matter in the organization of …
F Ullah, T dos Anjos-Garcia, IR dos Santos… - Behavioural Brain …, 2015 - Elsevier
Electrical stimulation of the periaqueductal gray matter and ventromedial hypothalamus in
humans showed the involvement of both these structures in panic attacks. The aim of this …
humans showed the involvement of both these structures in panic attacks. The aim of this …
The role of the brain's endocannabinoid system in pain and its modulation by stress
Stress has a complex, bidirectional modulatory influence on pain. Stress may either reduce
(stress-induced analgesia) or exacerbate (stress-induced hyperalgesia) pain depending on …
(stress-induced analgesia) or exacerbate (stress-induced hyperalgesia) pain depending on …