A cellular perspective on brain energy metabolism and functional imaging
PJ Magistretti, I Allaman - Neuron, 2015 - cell.com
The energy demands of the brain are high: they account for at least 20% of the body's
energy consumption. Evolutionary studies indicate that the emergence of higher cognitive …
energy consumption. Evolutionary studies indicate that the emergence of higher cognitive …
The pathobiology of vascular dementia
C Iadecola - Neuron, 2013 - cell.com
Vascular cognitive impairment defines alterations in cognition, ranging from subtle deficits to
full-blown dementia, attributable to cerebrovascular causes. Often coexisting with …
full-blown dementia, attributable to cerebrovascular causes. Often coexisting with …
Caveolae in CNS arterioles mediate neurovascular coupling
BW Chow, V Nuñez, L Kaplan, AJ Granger, K Bistrong… - Nature, 2020 - nature.com
Proper brain function depends on neurovascular coupling: neural activity rapidly increases
local blood flow to meet moment-to-moment changes in regional brain energy demand …
local blood flow to meet moment-to-moment changes in regional brain energy demand …
Entrainment of arteriole vasomotor fluctuations by neural activity is a basis of blood-oxygenation-level-dependent “resting-state” connectivity
Resting-state signals in blood-oxygenation-level-dependent (BOLD) imaging are used to
parcellate brain regions and define" functional connections" between regions. Yet a …
parcellate brain regions and define" functional connections" between regions. Yet a …
Ultra-slow oscillations in fMRI and resting-state connectivity: neuronal and vascular contributions and technical confounds
Summary Ultra-slow,∼ 0.1-Hz variations in the oxygenation level of brain blood are widely
used as an fMRI-based surrogate of" resting-state" neuronal activity. The temporal …
used as an fMRI-based surrogate of" resting-state" neuronal activity. The temporal …
The cortical angiome: an interconnected vascular network with noncolumnar patterns of blood flow
What is the nature of the vascular architecture in the cortex that allows the brain to meet the
energy demands of neuronal computations? We used high-throughput histology to …
energy demands of neuronal computations? We used high-throughput histology to …
Two-photon microscopy as a tool to study blood flow and neurovascular coupling in the rodent brain
The cerebral vascular system services the constant demand for energy during neuronal
activity in the brain. Attempts to delineate the logic of neurovascular coupling have been …
activity in the brain. Attempts to delineate the logic of neurovascular coupling have been …
Imaging faster neural dynamics with fast fMRI: A need for updated models of the hemodynamic response
JR Polimeni, LD Lewis - Progress in neurobiology, 2021 - Elsevier
Fast fMRI enables the detection of neural dynamics over timescales of hundreds of
milliseconds, suggesting it may provide a new avenue for studying subsecond neural …
milliseconds, suggesting it may provide a new avenue for studying subsecond neural …
Brain microvasculature has a common topology with local differences in geometry that match metabolic load
The microvasculature underlies the supply networks that support neuronal activity within
heterogeneous brain regions. What are common versus heterogeneous aspects of the …
heterogeneous brain regions. What are common versus heterogeneous aspects of the …
High-speed volumetric two-photon fluorescence imaging of neurovascular dynamics
Understanding the structure and function of vasculature in the brain requires us to monitor
distributed hemodynamics at high spatial and temporal resolution in three-dimensional (3D) …
distributed hemodynamics at high spatial and temporal resolution in three-dimensional (3D) …