Metastatic bone disease is a complex condition resulting from the migration and colonization
of cancer cells from their primary site to the bone microenvironment, where they typically …

Bone is a common organ for solid tumor metastasis. Malignant bone tumor becomes
insensitive to systemic therapy after colonization, followed by poor prognosis and high …

Fragility fractures, which are more prevalent in women, may be significantly influenced by
autophagy due to altered bone turnover. As an essential mediator of autophagy, Beclin-1 …

In this paper, we explore the effects of biological (pathological) and mechanical damage on
bone tissue within a benchmark model. Using the Finite Element Methodology, we analyze …

Bone cells contribute to tumour metastasis by producing biochemical factors that stimulate
tumour cell homing and proliferation, but also by resorbing bone matrix (osteolysis) that …

Breast cancer metastasises to bone in 70–80% of patients with advanced disease. Bone
cells contribute to tumour metastasis by activating bone resorption, which releases …