Preprocessing, analysis and quantification in single‐voxel magnetic resonance spectroscopy: experts' consensus recommendations

J Near, AD Harris, C Juchem, R Kreis… - NMR in …, 2021 - Wiley Online Library
Once an MRS dataset has been acquired, several important steps must be taken to obtain
the desired metabolite concentration measures. First, the data must be preprocessed to …

Terminology and concepts for the characterization of in vivo MR spectroscopy methods and MR spectra: background and experts' consensus recommendations

R Kreis, V Boer, IY Choi, C Cudalbu… - NMR in …, 2021 - Wiley Online Library
With a 40‐year history of use for in vivo studies, the terminology used to describe the
methodology and results of magnetic resonance spectroscopy (MRS) has grown …

Theoretical description of modern 1H in Vivo magnetic resonance spectroscopic pulse sequences

K Landheer, RF Schulte, MS Treacy… - Journal of Magnetic …, 2020 - Wiley Online Library
This article reviews the most commonly used modern sequences designed to confront the
two major challenges of in vivo magnetic resonance spectroscopy (MRS): spatial …

FSL‐MRS: An end‐to‐end spectroscopy analysis package

WT Clarke, CJ Stagg, S Jbabdi - Magnetic resonance in …, 2021 - Wiley Online Library
Purpose We introduce FSL‐MRS, an end‐to‐end, modular, open‐source MRS analysis
toolbox. It provides spectroscopic data conversion, preprocessing, spectral simulation, fitting …

Magnetic resonance Spectrum simulator (MARSS), a novel software package for fast and computationally efficient basis set simulation

K Landheer, KM Swanberg, C Juchem - NMR in Biomedicine, 2021 - Wiley Online Library
The aim of this study was to develop a novel software platform for the simulation of magnetic
resonance spin systems, capable of simulating a large number of spatial points (1283) for …

Are Cramér‐Rao lower bounds an accurate estimate for standard deviations in in vivo magnetic resonance spectroscopy?

K Landheer, C Juchem - NMR in Biomedicine, 2021 - Wiley Online Library
Due to inherent time constraints for in vivo experiments, it is infeasible to repeat multiple
MRS scans to estimate standard deviations on the desired measured parameters. As such …

Concentration and effective T2 relaxation times of macromolecules at 3T

K Landheer, M Gajdošík, M Treacy… - Magnetic Resonance in …, 2020 - Wiley Online Library
Purpose We aimed to investigate the concentration and effective T2 relaxation time of
macromolecules assessed with an ultra‐short TE sLASER sequence in 2 brain regions, the …

Multi‐echo single‐shot spectroscopy combined with simultaneous 2D model fitting for fast and accurate measurement of metabolite‐specific concentrations and T2 …

R Rizzo, R Kreis - NMR in Biomedicine, 2023 - Wiley Online Library
The purpose of the current study was to develop a novel single‐voxel MR spectroscopy
acquisition scheme to simultaneously determine metabolite‐specific concentrations and …

A semi‐LASER, single‐voxel spectroscopic sequence with a minimal echo time of 20.1 ms in the human brain at 3 T

K Landheer, M Gajdošík, C Juchem - NMR in Biomedicine, 2020 - Wiley Online Library
An optimized semi‐LASER sequence that is capable of acquiring artefact‐free data with an
echo time (TE) of 20.1 ms on a standard clinical 3 T MR system was developed. Simulations …

Simultaneous optimization of crusher and phase cycling schemes for magnetic resonance spectroscopy: an extension of dephasing optimization through coherence …

K Landheer, C Juchem - Magnetic Resonance in Medicine, 2020 - Wiley Online Library
Purpose To extend the dephasing optimization through coherence order pathway selection
(DOTCOPS) algorithm, originally designed solely for gradient crusher schemes, to include …