RNA helicases of the DEAD box and related DExD/H proteins form a very large superfamily
of proteins conserved from bacteria and viruses to humans. They have seven to eight …

Restriction enzymes are well known as reagents widely used by molecular biologists for
genetic manipulation and analysis, but these reagents represent only one class (type II) of a …

We have determined two different structures of PcrA DNA helicase complexed with the same
single strand tailed DNA duplex, providing snapshots of different steps on the catalytic …

Severe acute respiratory syndrome coronavirus (SARS-CoV), a newly identified group 2
coronavirus, is the causative agent of severe acute respiratory syndrome, a life-threatening …

RNA metabolism, broadly defined as the compendium of all processes that involve RNA,
including transcription, processing and modification of transcripts, translation, RNA …

The RecA protein is a recombinase functioning in recombinational DNA repair in bacteria.
RecA is regulated at many levels. The expression of the recA gene is regulated within the …

Helicases not only catalyse the disruption of hydrogen bonding between complementary
regions of nucleic acids, but also move along nucleic acid strands in a polar fashion. Here …

Members of the RNA-helicase family are defined by several evolutionary conserved motifs.
They are found in all organisms–from bacteria to humans–and many viruses. The minimum …

▪ Abstract The primary function of bacterial recombination systems is the nonmutagenic
repair of stalled or collapsed replication forks. The RecA protein plays a central role in these …

We have determined the crystal structure of an active, hexameric fragment of the gene 4
helicase from bacteriophage T7. The structure reveals how subunit contacts stabilize the …