[HTML][HTML] Top 10 challenges in cancer immunotherapy
Cancer immunotherapy is a validated and critically important approach for treating patients
with cancer. Given the vast research and clinical investigation efforts dedicated to advancing …
with cancer. Given the vast research and clinical investigation efforts dedicated to advancing …
[HTML][HTML] Current challenges and opportunities of photodynamic therapy against cancer
RV Huis in 't Veld, J Heuts, S Ma, LJ Cruz… - Pharmaceutics, 2023 - mdpi.com
BACKGROUND: Photodynamic therapy (PDT) is an established, minimally invasive
treatment for specific types of cancer. During PDT, reactive oxygen species (ROS) are …
treatment for specific types of cancer. During PDT, reactive oxygen species (ROS) are …
[HTML][HTML] Human immunology and immunotherapy: main achievements and challenges
J Varadé, S Magadán… - Cellular & Molecular …, 2021 - nature.com
The immune system is a fascinating world of cells, soluble factors, interacting cells, and
tissues, all of which are interconnected. The highly complex nature of the immune system …
tissues, all of which are interconnected. The highly complex nature of the immune system …
Immune escape mechanisms as a guide for cancer immunotherapy
GL Beatty, WL Gladney - Clinical cancer research, 2015 - AACR
Immunotherapy has demonstrated impressive outcomes for some patients with cancer.
However, selecting patients who are most likely to respond to immunotherapy remains a …
However, selecting patients who are most likely to respond to immunotherapy remains a …
[HTML][HTML] The urgent need to recover MHC class I in cancers for effective immunotherapy
Highlights•Tumor immune escape compromises the efficacy of cancer immunotherapy.•Loss
of MHC class I expression is a frequent event in cancer cells.•Three tumor phenotypes …
of MHC class I expression is a frequent event in cancer cells.•Three tumor phenotypes …
[HTML][HTML] Cancer vaccines, adjuvants, and delivery systems
SJ Paston, VA Brentville, P Symonds… - Frontiers in …, 2021 - frontiersin.org
Vaccination was first pioneered in the 18th century by Edward Jenner and eventually led to
the development of the smallpox vaccine and subsequently the eradication of smallpox. The …
the development of the smallpox vaccine and subsequently the eradication of smallpox. The …
[HTML][HTML] The role of natural killer T cells in cancer—a phenotypical and functional approach
D Krijgsman, M Hokland, PJK Kuppen - Frontiers in immunology, 2018 - frontiersin.org
Natural killer T (NKT) cells are a subset of CD1d-restricted T cells at the interface between
the innate and adaptive immune system. NKT cells can be subdivided into functional …
the innate and adaptive immune system. NKT cells can be subdivided into functional …
Poly-γ-glutamic acid nanoparticles as adjuvant and antigen carrier system for cancer vaccination
Vaccination is an innovative strategy for cancer treatment by leveraging various components
of the patients' immunity to boost an anti-tumor immune response. Rationally designed …
of the patients' immunity to boost an anti-tumor immune response. Rationally designed …
Cancer immune escape: MHC expression in primary tumours versus metastases
F Garrido, N Aptsiauri - Immunology, 2019 - Wiley Online Library
Tumours can escape T‐cell responses by losing major histocompatibility complex
(MHC)/human leucocyte antigen (HLA) class I molecules. In the early stages of cancer …
(MHC)/human leucocyte antigen (HLA) class I molecules. In the early stages of cancer …
B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells
T Azuma, S Yao, G Zhu, AS Flies… - Blood, The Journal of …, 2008 - ashpublications.org
B7-H1 is an immunoglobulin-like immune suppressive molecule broadly detectable on the
majority of human and rodent cancers, and its functions have been attributed to delivering …
majority of human and rodent cancers, and its functions have been attributed to delivering …