Numerous chemically modified oligonucleotides have been developed so far and show their
own unique chemical properties and pharmacodynamic/pharmacokinetic characteristics …

Restricting the sugar moiety of a nucleic acid to a single conformation can be accomplished
by forming a bridge in the sugar. A large number of bridged nucleic acids with variable …

Second-generation antisense oligonucleotides (ASOs) demonstrate excellent biological
stability and in vitro/in vivo potency, and thus are considered to be attractive candidates for …

There has been a growing interest in developing chemically modified nucleotides for
diagnostics or therapeutics. Among the list of the artificial nucleotides, bridged nucleic acids …

Stabilization of nucleic acid assemblies, such as duplex and triplex, is quite important for
their wide variety of potential applications. Various stabilization methods, including …

Conformationally locked 3′-azido-3′-deoxythymidine analogues of T, U, A and C
containing a 2′-O, 4′-C-methylene linked bicyclic furanose moiety has been efficiently …

A new synthesis protocol for the preparation of hitherto unknown 1′, 5′-anhydro-4′-
amino-trityl/MMTr hexitol nucleosides has been developed. Key steps in the synthesis of the …

Recent developments in genetic technologies for genomic analysis, diagnostics, and
therapeutics have revolutionary effects on medical science. Oligonucleotide (ON) molecules …

Extreme instability of pyrimidine motif triplex DNA at physiological pH severely limits its use
in wide variety of potential applications, such as artificial regulation of gene expression …

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(C) C) N3C [C@@ H](COP (= O)(N (C) C) N4C [C@@ H](COP (= O)(N (C) C) N5C [C …