The hnRNP family: insights into their role in health and disease
T Geuens, D Bouhy, V Timmerman - Human genetics, 2016 - Springer
Heterogeneous nuclear ribonucleoproteins (hnRNPs) represent a large family of RNA-
binding proteins (RBPs) that contribute to multiple aspects of nucleic acid metabolism …
binding proteins (RBPs) that contribute to multiple aspects of nucleic acid metabolism …
[HTML][HTML] Alternative splicing in the mammalian nervous system: recent insights into mechanisms and functional roles
B Raj, BJ Blencowe - Neuron, 2015 - cell.com
High-throughput transcriptomic profiling approaches have revealed that alternative splicing
(AS) of precursor mRNAs, a fundamental process by which cells expand their transcriptomic …
(AS) of precursor mRNAs, a fundamental process by which cells expand their transcriptomic …
Complexity of the alternative splicing landscape in plants
Alternative splicing (AS) of precursor mRNAs (pre-mRNAs) from multiexon genes allows
organisms to increase their coding potential and regulate gene expression through multiple …
organisms to increase their coding potential and regulate gene expression through multiple …
RBPmap: a web server for mapping binding sites of RNA-binding proteins
Regulation of gene expression is executed in many cases by RNA-binding proteins (RBPs)
that bind to mRNAs as well as to non-coding RNAs. RBPs recognize their RNA target via …
that bind to mRNAs as well as to non-coding RNAs. RBPs recognize their RNA target via …
Alternative mRNA transcription, processing, and translation: insights from RNA sequencing
E de Klerk, P AC't Hoen - Trends in Genetics, 2015 - cell.com
The human transcriptome comprises> 80000 protein-coding transcripts and the estimated
number of proteins synthesized from these transcripts is in the range of 250000 to 1 million …
number of proteins synthesized from these transcripts is in the range of 250000 to 1 million …
Precise temporal regulation of alternative splicing during neural development
SM Weyn-Vanhentenryck, H Feng… - Nature …, 2018 - nature.com
Alternative splicing (AS) is one crucial step of gene expression that must be tightly regulated
during neurodevelopment. However, the precise timing of developmental splicing switches …
during neurodevelopment. However, the precise timing of developmental splicing switches …
[HTML][HTML] HITS-CLIP and integrative modeling define the Rbfox splicing-regulatory network linked to brain development and autism
The RNA binding proteins Rbfox1/2/3 regulate alternative splicing in the nervous system,
and disruption of Rbfox1 has been implicated in autism. However, comprehensive …
and disruption of Rbfox1 has been implicated in autism. However, comprehensive …
GraphProt: modeling binding preferences of RNA-binding proteins
We present GraphProt, a computational framework for learning sequence-and structure-
binding preferences of RNA-binding proteins (RBPs) from high-throughput experimental …
binding preferences of RNA-binding proteins (RBPs) from high-throughput experimental …
Compound loss of muscleblind‐like function in myotonic dystrophy
Myotonic dystrophy (DM) is a multi‐systemic disease that impacts cardiac and skeletal
muscle as well as the central nervous system (CNS). DM is unusual because it is an RNA …
muscle as well as the central nervous system (CNS). DM is unusual because it is an RNA …
MBNL sequestration by toxic RNAs and RNA misprocessing in the myotonic dystrophy brain
For some neurological disorders, disease is primarily RNA mediated due to expression of
non-coding microsatellite expansion RNAs (RNA exp). Toxicity is thought to result from …
non-coding microsatellite expansion RNAs (RNA exp). Toxicity is thought to result from …