Determinants for the development of visceral leishmaniasis disease

LI McCall, WW Zhang, G Matlashewski - PLoS pathogens, 2013 - journals.plos.org
Leishmaniasis is a vector-borne neglected tropical disease associated with a spectrum of
clinical manifestations, ranging from self-healing cutaneous lesions to fatal visceral …

Gene expression regulation in trypanosomatids

JG De Gaudenzi, G Noé, VA Campo… - Essays in …, 2011 - portlandpress.com
Trypanosomatids are protozoan micro-organisms that cause serious health problems in
humans and domestic animals. In addition to their medical relevance, these pathogens have …

Genome sequencing of the lizard parasite Leishmania tarentolae reveals loss of genes associated to the intracellular stage of human pathogenic species

F Raymond, S Boisvert, G Roy, JF Ritt… - Nucleic acids …, 2012 - academic.oup.com
Abstract The Leishmania tarentolae Parrot-TarII strain genome sequence was resolved to an
average 16-fold mean coverage by next-generation DNA sequencing technologies. This is …

Gene expression modulation is associated with gene amplification, supernumerary chromosomes and chromosome loss in antimony-resistant Leishmania infantum

P Leprohon, D Legare, F Raymond… - Nucleic acids …, 2009 - academic.oup.com
Antimonials remain the first line drug against the protozoan parasite Leishmania but their
efficacy is threatened by resistance. We carried out a RNA expression profiling analysis …

The Genome Sequence of Leishmania (Leishmania) amazonensis: Functional Annotation and Extended Analysis of Gene Models

F Real, RO Vidal, MF Carazzolle, JMC Mondego… - DNA …, 2013 - academic.oup.com
We present the sequencing and annotation of the Leishmania (Leishmania) amazonensis
genome, an etiological agent of human cutaneous leishmaniasis in the Amazon region of …

Iron uptake controls the generation of Leishmania infective forms through regulation of ROS levels

B Mittra, M Cortez, A Haydock, G Ramasamy… - Journal of Experimental …, 2013 - rupress.org
During its life cycle, Leishmania undergoes extreme environmental changes, alternating
between insect vectors and vertebrate hosts. Elevated temperature and decreased pH …

Gene Expression in Leishmania Is Regulated Predominantly by Gene Dosage

SA Iantorno, C Durrant, A Khan, MJ Sanders… - MBio, 2017 - Am Soc Microbiol
Leishmania tropica, a unicellular eukaryotic parasite present in North and East Africa, the
Middle East, and the Indian subcontinent, has been linked to large outbreaks of cutaneous …

Simultaneous transcriptional profiling of Leishmania major and its murine macrophage host cell reveals insights into host-pathogen interactions

LAL Dillon, R Suresh, K Okrah, H Corrada Bravo… - BMC genomics, 2015 - Springer
Background Parasites of the genus Leishmania are the causative agents of leishmaniasis, a
group of diseases that range in manifestations from skin lesions to fatal visceral disease …

The steady-state transcriptome of the four major life-cycle stages of Trypanosoma cruzi

TA Minning, DB Weatherly, J Atwood, R Orlando… - BMC genomics, 2009 - Springer
Background Chronic chagasic cardiomyopathy is a debilitating and frequently fatal outcome
of human infection with the protozoan parasite, Trypanosoma cruzi. Microarray analysis of …

Transcriptomic profiling of gene expression and RNA processing during Leishmania major differentiation

LAL Dillon, K Okrah, VK Hughitt, R Suresh… - Nucleic acids …, 2015 - academic.oup.com
Protozoan parasites of the genus Leishmania are the etiological agents of leishmaniasis, a
group of diseases with a worldwide incidence of 0.9–1.6 million cases per year. We used …