Sequencing the human genome empowers translational medicine, facilitating transcriptome‐
wide molecular diagnosis, pathway biology, and drug repositioning. Initially, microarrays are …

Radial glial cells (RGCs) as primary neural stem cells in the developing mammalian cortex
give rise to diverse types of neurons and glial cells according to sophisticated …

Increasing evidence implicates the critical roles of various epitranscriptomic RNA
modifications in different biological processes. Methyltransferase METTL8 installs 3 …

Determining whether the RNA isoforms from medically relevant genes have distinct
functions could facilitate direct targeting of RNA isoforms for disease treatment. Here, as a …

Due to alternative splicing, human protein-coding genes average over eight RNA isoforms,
resulting in nearly four distinct protein coding sequences per gene. Long-read RNAseq …

Alternative transcription increases transcriptome complexity by expression of multiple
transcripts per gene. Annotation and quantification of transcripts using short-read …

Transcriptomics is the study of RNA transcripts, the portion of the genome that is transcribed,
in a specific cell, tissue, or organism. Transcriptomics provides insight into gene expression …

Exitron splicing is a type of alternative splicing where coding sequences are spliced out.
Recently, exitron splicing has been shown to increase proteome plasticity and play a role in …

Kazakh mares have attracted widespread attention with their outstanding lactation traits.
Lactation is a complex dynamic process regulated by multiple factors. The extensive …

Cancer is the second main cause of death in the world, and genetic variation influences a
large proportion of its risk. This thesis combined GWAS, 3D chromatin organisation and …