Milling involves the application of mechanical energy to physically break down coarse
particles to finer ones and is regarded as a “top–down” approach in the production of fine …

In recent years, the coamorphous drug delivery system has been established as a promising
formulation approach for delivering poorly water-soluble drugs. The coamorphous solid is a …

The combination of oral antidiabetic drugs, pioglitazone, metformin, and glibenclamide,
which also exhibit the strongest anti-inflammatory action among oral antidiabetic drugs …

Almost half of orally administered active pharmaceutical ingredients (APIs) have low
solubility, which affects their bioavailability. In the last two decades, several alternatives …

Enhancing the solubility of active drug ingredients is a major challenge faced by scientists
and researchers. Different approaches have been explored for the enhancement of solubility …

The milling of materials at cryogenic temperature has gained importance both in academic
as well as the industrial community in the last two decades, primarily because of distinct …

Co-amorphous drug mixtures with low-molecular-weight excipients have recently been
shown to be a promising approach for stabilization of amorphous drugs and thus to be an …

Low physical stability is the main reason limiting the widespread use of amorphous
pharmaceuticals. One approach to overcome this problem is to mix these drugs with various …

From an exhaustive examination of the molecular dynamics in practically all van der Waals
molecular glass formers ever probed by dielectric spectroscopy, we found that the width of …

We present a novel computational tool which predicts the glass-forming ability of drug
compounds solely from their molecular structure. Compounds which show solid-state limited …