Phase separation in biological membranes: integration of theory and experiment
Lipid bilayer model membranes that contain a single lipid species can undergo transitions
between ordered and disordered phases, and membranes that contain a mixture of lipid …
between ordered and disordered phases, and membranes that contain a mixture of lipid …
The more the merrier: effects of macromolecular crowding on the structure and dynamics of biological membranes
M Löwe, M Kalacheva, AJ Boersma… - The FEBS …, 2020 - Wiley Online Library
Proteins are essential and abundant components of cellular membranes. Being densely
packed within the limited surface area, proteins fulfil essential tasks for life, which include …
packed within the limited surface area, proteins fulfil essential tasks for life, which include …
Spatial control of EGF receptor activation by reversible dimerization on living cells
Epidermal growth factor receptor (EGFR) is a type I receptor tyrosine kinase, the
deregulation of which has been implicated in a variety of human carcinomas,,,. EGFR …
deregulation of which has been implicated in a variety of human carcinomas,,,. EGFR …
Lateral diffusion of membrane proteins
S Ramadurai, A Holt, V Krasnikov… - Journal of the …, 2009 - ACS Publications
We measured the lateral mobility of integral membrane proteins reconstituted in giant
unilamellar vesicles (GUVs), using fluorescence correlation spectroscopy. Receptor …
unilamellar vesicles (GUVs), using fluorescence correlation spectroscopy. Receptor …
[HTML][HTML] Reduced lateral mobility of lipids and proteins in crowded membranes
JE Goose, MSP Sansom - PLoS computational biology, 2013 - journals.plos.org
Coarse-grained molecular dynamics simulations of the E. coli outer membrane proteins
FhuA, LamB, NanC, OmpA and OmpF in a POPE/POPG (3∶ 1) bilayer were performed to …
FhuA, LamB, NanC, OmpA and OmpF in a POPE/POPG (3∶ 1) bilayer were performed to …
H-Ras forms dimers on membrane surfaces via a protein–protein interface
The lipid-anchored small GTPase Ras is an important signaling node in mammalian cells. A
number of observations suggest that Ras is laterally organized within the cell membrane …
number of observations suggest that Ras is laterally organized within the cell membrane …
[HTML][HTML] Single molecule diffusion of membrane-bound proteins: window into lipid contacts and bilayer dynamics
Membrane targeting proteins are recruited to specific membranes during cell signaling
events, including signals at the leading edge of chemotaxing cells. Recognition and binding …
events, including signals at the leading edge of chemotaxing cells. Recognition and binding …
[HTML][HTML] A vesicle microrheometer for high-throughput viscosity measurements of lipid and polymer membranes
Viscosity is a key property of cell membranes that controls mobility of embedded proteins
and membrane remodeling. Measuring it is challenging because existing approaches …
and membrane remodeling. Measuring it is challenging because existing approaches …
Lipid and Peptide Diffusion in Bilayers: The Saffman–Delbrück Model and Periodic Boundary Conditions
RM Venable, HI Ingólfsson, MG Lerner… - The Journal of …, 2017 - ACS Publications
The periodic Saffman–Delbrück (PSD) model, an extension of the Saffman–Delbrück
model developed to describe the effects of periodic boundary conditions on the diffusion …
model developed to describe the effects of periodic boundary conditions on the diffusion …
Single-molecule imaging of glycan–lectin interactions on cells with Glyco-PAINT
Most lectins bind carbohydrate ligands with relatively low affinity, making the identification of
optimal ligands challenging. Here we introduce a point accumulation in nanoscale …
optimal ligands challenging. Here we introduce a point accumulation in nanoscale …