As the home of cellular genetic information, the nucleus has a critical role in determining cell
fate and function in response to various signals and stimuli. In addition to biochemical …

Living cells are constantly exposed to mechanical stimuli arising from the surrounding
extracellular matrix (ECM) or from neighboring cells. The intracellular molecular processes …

Mechanical force controls fundamental cellular processes in health and disease, and
increasing evidence shows that the nucleus both experiences and senses applied forces …

YAP is a mechanosensitive transcriptional activator with a critical role in cancer,
regeneration, and organ size control. Here, we show that force applied to the nucleus …

The ability of cells to respond to mechanical forces is critical for numerous biological
processes. Emerging evidence indicates that external mechanical forces trigger changes in …

Mechanical forces play critical roles in the function of living cells. However, the underlying
mechanisms of how forces influence nuclear events remain elusive. Here, we show that …

Cues from the extracellular environment, including physical stimuli, are well known to affect
mesenchymal stem cell (MSC) properties in terms of proliferation and differentiation. Many …

The cell nucleus must continually resist and respond to intercellular and intracellular
mechanical forces to transduce mechanical signals and maintain proper genome …

Introduction Tissues can be soft like brain, bone marrow, and fat, which bear little
mechanical stress, or stiff like muscle, cartilage, and bone, which sustain high levels of …

Background: Myocardial metabolic impairment is a major feature in chronic heart failure. As
the major coenzyme in fuel oxidation and oxidative phosphorylation and a substrate for …