Mitochondria are organelles that are able to adjust and respond to different stressors and
metabolic needs within a cell, showcasing their plasticity and dynamic nature. These …

Its increasing incidence has led stroke to be the second leading cause of death worldwide.
Despite significant advances in recanalization strategies, patients are still at risk for …

The NLRP3 inflammasome is linked to sterile and pathogen-dependent inflammation, and
its dysregulation underlies many chronic diseases. Mitochondria have been implicated as …

Cellular metabolism orchestrates the intricate use of tissue fuels for catabolism and
anabolism to generate cellular energy and structural components. The emerging field of …

The process of pyroptosis is mediated by inflammasomes and a downstream effector known
as gasdermin D (GSDMD). Upon cleavage by inflammasome-associated caspases, the N …

Reactive oxygen species (ROS) are fundamental for macrophages to eliminate invasive
microorganisms. However, as observed in nonphagocytic cells, ROS play essential roles in …

Ferroptosis, a newly discovered iron-dependent cell death pathway, is characterized by lipid
peroxidation and GSH depletion mediated by iron metabolism and is morphologically …

Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …

Reactive oxygen species (ROS) are a chemically defined group of reactive molecules
derived from molecular oxygen. ROS are involved in a plethora of processes in cells in all …

Mitochondria are traditionally known as the powerhouse of the cell, but their functions
extend far beyond energy production. They are vital in cellular and organismal pathways …