Absence of a simple code: how transcription factors read the genome
Transcription factors (TFs) influence cell fate by interpreting the regulatory DNA within a
genome. TFs recognize DNA in a specific manner; the mechanisms underlying this …
genome. TFs recognize DNA in a specific manner; the mechanisms underlying this …
From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications
SM Hattangadi, P Wong, L Zhang… - Blood, The Journal …, 2011 - ashpublications.org
This article reviews the regulation of production of RBCs at several levels. We focus on the
regulated expansion of burst-forming unit-erythroid erythroid progenitors by glucocorticoids …
regulated expansion of burst-forming unit-erythroid erythroid progenitors by glucocorticoids …
Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex
INTRODUCTION The cerebral cortex is a cellularly heterogeneous structure whose
neuronal circuits underlie high-order cognitive and sensorimotor information processing …
neuronal circuits underlie high-order cognitive and sensorimotor information processing …
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …
Since then, this topic has received increasing attention, and many scientists have entered …
[HTML][HTML] Anticancer chemotherapy-induced intratumoral recruitment and differentiation of antigen-presenting cells
Y Ma, S Adjemian, SR Mattarollo, T Yamazaki… - Immunity, 2013 - cell.com
The therapeutic efficacy of anthracyclines relies on antitumor immune responses elicited by
dying cancer cells. How chemotherapy-induced cell death leads to efficient antigen …
dying cancer cells. How chemotherapy-induced cell death leads to efficient antigen …
[HTML][HTML] HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers
Summary Heat-Shock Factor 1 (HSF1), master regulator of the heat-shock response,
facilitates malignant transformation, cancer cell survival, and proliferation in model systems …
facilitates malignant transformation, cancer cell survival, and proliferation in model systems …
Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators
Combinatorial transcription factor (TF) interactions control cellular phenotypes and,
therefore, underpin stem cell formation, maintenance, and differentiation. Here, we report the …
therefore, underpin stem cell formation, maintenance, and differentiation. Here, we report the …
MAnorm: a robust model for quantitative comparison of ChIP-Seq data sets
ChIP-Seq is widely used to characterize genome-wide binding patterns of transcription
factors and other chromatin-associated proteins. Although comparison of ChIP-Seq data …
factors and other chromatin-associated proteins. Although comparison of ChIP-Seq data …
Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5
XP Yang, K Ghoreschi, SM Steward-Tharp… - Nature …, 2011 - nature.com
Abstract Interleukin 2 (IL-2), a cytokine linked to human autoimmune disease, limits IL-17
production. Here we found that deletion of the gene encoding the transcription factor STAT3 …
production. Here we found that deletion of the gene encoding the transcription factor STAT3 …
Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia
The CEBPA gene is mutated in 9% of patients with acute myeloid leukemia (AML). Selective
expression of a short (30-kDa) CCAAT-enhancer binding protein-α (C/EBPα) translational …
expression of a short (30-kDa) CCAAT-enhancer binding protein-α (C/EBPα) translational …