T-type calcium channels regulate neuronal excitability and are important contributors of pain
processing. CaV3. 2 channels are the major isoform expressed in nonpeptidergic and …

Although voltage-activated Ca2+ channels are a common feature in excitable cells, their
expression in cancer tissue is less understood. T-type Ca2+ channels are particularly …

The spontaneous contractions of collecting lymphatic vessels provide an essential
propulsive force to return lymph centrally. These contractions are driven by an intrinsic …

How nature discriminates sodium from calcium ions in eukaryotic channels has been difficult
to resolve because they contain four homologous, but markedly different repeat domains …

Cav3 channels play an important role in modulating chronic pain. However, less is known
about the functional changes of Cav3 channels in superficial spinal dorsal horn in …

Much of our understanding of dendritic and synaptic physiology comes from in vitro
experimentation, where the afforded mechanical stability and convenience of applying drugs …

Voltage-gated calcium ion channels are essential for numerous biological functions of
excitable cells and there is wide spread appreciation of their importance as drug targets in …

T-type calcium channels (TTCCs) are overexpressed in several cancers. In this review, we
summarize the recent advances and new insights into TTCC biology, tumor progression …

Calcium (Ca v 1 and Ca v 2) and sodium channels possess homologous CaM-binding
motifs, known as IQ motifs in their C termini, which associate with calmodulin (CaM), a …

T-type calcium channels are key contributors to neuronal physiology where they shape
electrical activity of nerve cells and contribute to the release of neurotransmitters. Enhanced …