Caveolin-1, breast cancer and ionizing radiation
M Pucci, V Bravata, GI Forte… - Cancer genomics & …, 2015 - cgp.iiarjournals.org
Breast cancer (BC) recovery has increased in recent years thanks to efforts of Omics-based
research in this field. However, despite the important results obtained, BC remains a …
research in this field. However, despite the important results obtained, BC remains a …
Micro-SPECT/CT with 111In-DTPA-pertuzumab sensitively detects trastuzumab-mediated HER2 downregulation and tumor response in athymic mice bearing MDA …
K McLarty, B Cornelissen, Z Cai… - Journal of Nuclear …, 2009 - Soc Nuclear Med
Pertuzumab is a HER2 dimerization inhibitor that binds to an epitope unique from that of
trastuzumab. Our objective was to determine whether SPECT with 111In …
trastuzumab. Our objective was to determine whether SPECT with 111In …
Peptide-functionalized ZCIS QDs as fluorescent nanoprobe for targeted HER2-positive breast cancer cells imaging
M Michalska, A Florczak, H Dams-Kozlowska… - Acta biomaterialia, 2016 - Elsevier
In this paper, the synthesis of alloyed CuInZn x S 2+ x quantum dots (ZCIS QDs), their
transfer into aqueous solution via a polymer coating technique, and the use of these …
transfer into aqueous solution via a polymer coating technique, and the use of these …
[HTML][HTML] Therapeutic potential of an anti-HER2 single chain antibody–DM1 conjugates for the treatment of HER2-positive cancer
H Zhang, Y Wang, Y Wu, X Jiang, Y Tao… - Signal transduction and …, 2017 - nature.com
Antibody–drug conjugates (ADCs) take the advantage of monoclonal antibodies to
selectively deliver highly potent cytotoxic drugs to tumor cells, which have become a …
selectively deliver highly potent cytotoxic drugs to tumor cells, which have become a …
Construction and Characterization of Novel, Recombinant Immunotoxins Targeting the Her2/neu Oncogene Product: In vitro and In vivo Studies
Y Cao, JD Marks, JW Marks, LH Cheung, S Kim… - Cancer research, 2009 - AACR
The goal of this study was to characterize a series of anti-Her2/neu immunotoxin constructs
to identify how different antibodies and linker choices affect the specificity and cytotoxicity of …
to identify how different antibodies and linker choices affect the specificity and cytotoxicity of …
[HTML][HTML] Identification of caveolin-1 as a potential causative factor in the generation of trastuzumab resistance in breast cancer cells
The oncogenic tyrosine kinase receptor ErbB2 is a prognostic factor and target for breast
cancer therapeutics. In contrast with the other ErbB receptors, ErbB2 is hardly internalized …
cancer therapeutics. In contrast with the other ErbB receptors, ErbB2 is hardly internalized …
[HTML][HTML] A kinase inhibitor screen reveals protein kinase C-dependent endocytic recycling of ErbB2 in breast cancer cells
TA Bailey, H Luan, E Tom, TA Bielecki… - Journal of Biological …, 2014 - ASBMB
ErbB2 overexpression drives oncogenesis in 20–30% cases of breast cancer. Oncogenic
potential of ErbB2 is linked to inefficient endocytic traffic into lysosomes and preferential …
potential of ErbB2 is linked to inefficient endocytic traffic into lysosomes and preferential …
Development of a bifunctional immunoliposome system for combined drug delivery and imaging in vivo
B Feng, K Tomizawa, H Michiue, XJ Han, S Miyatake… - Biomaterials, 2010 - Elsevier
The diverse characteristics of immunoliposomes provide advantages for utilization in drug
delivery systems. In this study, we fused the antibody affinity motif of protein A (ZZ) with …
delivery systems. In this study, we fused the antibody affinity motif of protein A (ZZ) with …
[HTML][HTML] HER2-specific recombinant immunotoxin 4D5scFv-PE40 passes through retrograde trafficking route and forces cells to enter apoptosis
E Sokolova, E Guryev, A Yudintsev, V Vodeneev… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Abstract Immunotoxin 4D5scFv-PE40 is a recombinant protein that comprises 4D5scFv
antibody as a targeting module and fragment of Pseudomonas exotoxin A as an effector …
antibody as a targeting module and fragment of Pseudomonas exotoxin A as an effector …
Chlorotoxin‐Fc fusion inhibits release of MMP‐2 from pancreatic cancer cells
S El-Ghlban, T Kasai, T Shigehiro… - BioMed research …, 2014 - Wiley Online Library
Chlorotoxin (CTX) is a 36‐amino acid peptide derived from Leiurus quinquestriatus
(scorpion) venom, which inhibits low‐conductance chloride channels in colonic epithelial …
(scorpion) venom, which inhibits low‐conductance chloride channels in colonic epithelial …