Aryl hydrocarbon receptor ligands in cancer: friend and foe
IA Murray, AD Patterson, GH Perdew - Nature Reviews Cancer, 2014 - nature.com
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that is best
known for mediating the toxicity and tumour-promoting properties of the carcinogen 2, 3, 7, 8 …
known for mediating the toxicity and tumour-promoting properties of the carcinogen 2, 3, 7, 8 …
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in …
P Godoy, NJ Hewitt, U Albrecht, ME Andersen… - Archives of …, 2013 - Springer
This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …
Risk for animal and human health related to the presence of dioxins and dioxin‐like PCBs in feed and food
EFSA Panel on Contaminants in the Food Chain … - Efsa …, 2018 - Wiley Online Library
Abstract The European Commission asked EFSA for a scientific opinion on the risks for
animal and human health related to the presence of dioxins (PCDD/Fs) and DL‐PCBs in …
animal and human health related to the presence of dioxins (PCDD/Fs) and DL‐PCBs in …
Omics advances in ecotoxicology
Toxic substances in the environment generate adverse effects at all levels of biological
organization from the molecular level to community and ecosystem. Given this complexity, it …
organization from the molecular level to community and ecosystem. Given this complexity, it …
Recommended approaches in the application of toxicogenomics to derive points of departure for chemical risk assessment
R Farmahin, A Williams, B Kuo, NL Chepelev… - Archives of …, 2017 - Springer
There is increasing interest in the use of quantitative transcriptomic data to determine
benchmark dose (BMD) and estimate a point of departure (POD) for human health risk …
benchmark dose (BMD) and estimate a point of departure (POD) for human health risk …
Comparison of toxicogenomics and traditional approaches to inform mode of action and points of departure in human health risk assessment of benzo[a]pyrene in …
I Moffat, NL Chepelev, S Labib… - Critical reviews in …, 2015 - Taylor & Francis
Toxicogenomics is proposed to be a useful tool in human health risk assessment. However,
a systematic comparison of traditional risk assessment approaches with those applying …
a systematic comparison of traditional risk assessment approaches with those applying …
Nano-risk Science: application of toxicogenomics in an adverse outcome pathway framework for risk assessment of multi-walled carbon nanotubes
S Labib, A Williams, CL Yauk, JK Nikota… - Particle and fibre …, 2015 - Springer
Background A diverse class of engineered nanomaterials (ENMs) exhibiting a wide array of
physical-chemical properties that are associated with toxicological effects in experimental …
physical-chemical properties that are associated with toxicological effects in experimental …
AHR function in lymphocytes: emerging concepts
L Zhou - Trends in immunology, 2016 - cell.com
The aryl hydrocarbon receptor (AHR) is an important regulator of the development and
function of both innate and adaptive immune cells through roles associated with AHR's …
function of both innate and adaptive immune cells through roles associated with AHR's …
The role of AhR in transcriptional regulation of immune cell development and function
P Trikha, DA Lee - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2020 - Elsevier
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcriptional factor (TF) that is a
member of the Per-Arnt-Sim family of proteins. AhR regulates diverse processes, including …
member of the Per-Arnt-Sim family of proteins. AhR regulates diverse processes, including …
The 2022 world health organization reevaluation of human and mammalian toxic equivalency factors for polychlorinated dioxins, dibenzofurans and biphenyls
M DeVito, B Bokkers, MBM van Duursen… - Regulatory Toxicology …, 2024 - Elsevier
Abstract In October 2022, the World Health Organization (WHO) convened an expert panel
in Lisbon, Portugal in which the 2005 WHO TEFs for chlorinated dioxin-like compounds …
in Lisbon, Portugal in which the 2005 WHO TEFs for chlorinated dioxin-like compounds …