Causal relationships involving brain imaging-derived phenotypes based on UKB imaging cohort: a review of Mendelian randomization studies
M Wang, Z Wang, Y Wang, Q Zhou… - Frontiers in Neuroscience, 2024 - frontiersin.org
The UK Biobank (UKB) has the largest adult brain imaging dataset, which encompasses
over 40,000 participants. A significant number of Mendelian randomization (MR) studies …
over 40,000 participants. A significant number of Mendelian randomization (MR) studies …
Evidence for genetic causal relationships between gut microbiome, metabolites, and myasthenia gravis: a bidirectional Mendelian randomization study
D Sheng, S Wang, P Li, J Li, Z Xiao, H Lv… - Frontiers in …, 2023 - frontiersin.org
Background Myasthenia gravis (MG) is an autoimmune disease observed to have
connections with gut microbiome. We aimed to systematically assess the causal …
connections with gut microbiome. We aimed to systematically assess the causal …
Unraveling the causal relationships between depression and brain structural imaging phenotypes: A bidirectional Mendelian Randomization study
W Wang, W Jia, S Wang, Y Wang, Z Zhang, M Lei… - Brain Research, 2024 - Elsevier
Background Previous studies have revealed structural brain abnormalities in individuals
with depression, but the causal relationship between depression and brain structure …
with depression, but the causal relationship between depression and brain structure …
[HTML][HTML] The causal relationship between major depression disorder and thyroid diseases: A Mendelian randomization study and mediation analysis
X Zhang, Q Lu, Y Luo, L Wang, Y Tian, X Luo - Journal of Affective …, 2024 - Elsevier
Background Studies have been conducted on the relationship between depression and
thyroid diseases and function, its causal relationship remains unclear. Methods Using …
thyroid diseases and function, its causal relationship remains unclear. Methods Using …
Shared genetic architecture and causal pathways between attention deficit hyperactivity disorder and restless legs syndrome
FJ Li, JY Li, RY Zhang, XJ Liu, BC Lv, T Zhang, YN Liu… - medRxiv, 2024 - medrxiv.org
Previous studies have revealed a significant overlap between ADHD and RLS populations,
with shared pathological mechanisms such as dopaminergic function and iron metabolism …
with shared pathological mechanisms such as dopaminergic function and iron metabolism …
A commentary on “Complex causal association between genetically predicted 731 immunocyte phenotype and osteonecrosis: A bidirectional Two-sample mendelian …
X Zhu, B Huang, J Zhao, C Yin, X Li, J Zuo… - … Journal of Surgery, 2024 - journals.lww.com
The journal requires authors to include in any articles that report results derived from
research data to include a Data Availability Statement. Please confirm if any datasets …
research data to include a Data Availability Statement. Please confirm if any datasets …
Causal association between atorvastatin use and erectile dysfunction in European population: a Mendelian randomization study
X Jin, J Wu, J Li, W Ma, N Jiang, J Yan, S Tai, J Wang - 2024 - researchsquare.com
Atorvastatin, a common cardiovascular drug, lowers cholesterol but its link to erectile
dysfunction (ED) risk is unclear. This study uses a two-sample MR approach to clarify this …
dysfunction (ED) risk is unclear. This study uses a two-sample MR approach to clarify this …
Exploring the association between lipid-modifying drugs and idiopathic pulmonary fibrosis: a drug-target Mendelian randomization study
G Cai, J Liu, M Cai, L Shao - 2024 - researchsquare.com
Background Idiopathic pulmonary fibrosis (IPF) is a respiratory disorder of obscure etiology
and limited treatment options, possibly linked to dysregulation in lipid metabolism. While …
and limited treatment options, possibly linked to dysregulation in lipid metabolism. While …
Causality between cathepsins and idiopathic pulmonary fibrosis: a Mendelian randomization study
Z Zhong, R Xu, C Xu, Y Zhu, Q Xu, Y Hua - 2024 - researchsquare.com
Background The pathogenesis of idiopathic pulmonary fibrosis (IPF) is complex and difficult
to diagnose and treat clinically. Cathepsins are involved in various physiological and …
to diagnose and treat clinically. Cathepsins are involved in various physiological and …