Heterocyclic compounds as synthetic tyrosinase inhibitors: recent advances
Tyrosinase is a copper-containing enzyme which is widely distributed in nature (eg, bacteria,
mammals, fungi) and involved in two consecutive steps of melanin biosynthesis. In humans …
mammals, fungi) and involved in two consecutive steps of melanin biosynthesis. In humans …
Syntheses, reactivity, and biological applications of coumarins
This comprehensive review, covering 2021–2023, explores the multifaceted chemical and
pharmacological potential of coumarins, emphasizing their significance as versatile natural …
pharmacological potential of coumarins, emphasizing their significance as versatile natural …
Synthesis, Anti-Tyrosinase Activity, and Spectroscopic Inhibition Mechanism of Cinnamic Acid–Eugenol Esters
J Li, X Min, X Zheng, S Wang, X Xu, J Peng - Molecules, 2023 - mdpi.com
Tyrosinase plays crucial roles in mediating the production of melanin pigment; thus, its
inhibitors could be useful in preventing melanin-related diseases. To find potential …
inhibitors could be useful in preventing melanin-related diseases. To find potential …
A facile green synthesis of 3, 4-dihydropyrimidin-2 (1H)-ones using cysteine as a bio-organic catalyst: Potent urease inhibitors, in vitro evaluation, kinetic mechanism …
The aim of the present research was to develop a one-pot, three-component method for the
synthesis of some 3, 4-dihydro pyrimidine-2-(1H)-one (DHPM) derivatives using aldehydes …
synthesis of some 3, 4-dihydro pyrimidine-2-(1H)-one (DHPM) derivatives using aldehydes …
In vitro and in vivo biological evaluation of indole-thiazolidine-2, 4-dione derivatives as tyrosinase inhibitors
L Lu, C Hu, X Min, Z Liu, X Xu, L Gan - Molecules, 2023 - mdpi.com
Tyrosinase is an important rate-limiting enzyme in melanin biosynthesis. To find potential
tyrosinase inhibitors with anti-melanogenic activity, a series of indole-thiazolidine-2, 4-dione …
tyrosinase inhibitors with anti-melanogenic activity, a series of indole-thiazolidine-2, 4-dione …
Rosa× damascena Herrm. essential oil: anti-tyrosinase activity and phytochemical composition
Q Wu, W Fang, H Liu, Z Liu, X Xu - Frontiers in Pharmacology, 2024 - frontiersin.org
Tyrosinase is a key enzyme in melanin synthesis, and its natural inhibitors are receiving
increasing attention. Rosa× damascena Herrm. essential oil (RDEO), as important functional …
increasing attention. Rosa× damascena Herrm. essential oil (RDEO), as important functional …
Design and synthesis of thiadiazole-oxadiazole-acetamide derivatives: Elastase inhibition, cytotoxicity, kinetic mechanism, and computational studies
Considering the biological significance of 1, 3, 4-thiadiazole/oxadiazole heterocyclic
scaffolds, a novel series of 1, 3, 4-thiadiazole-1, 3, 4-oxadiazole-acetamide derivatives (7a …
scaffolds, a novel series of 1, 3, 4-thiadiazole-1, 3, 4-oxadiazole-acetamide derivatives (7a …
Exploring the anti-Alzheimer potential: Design, synthesis, biological activity, and molecular docking study of benzothiazol-1, 3, 4-oxadiazole-acetamide compounds
In this research, a series of benzothiazol-1, 3, 4-oxadiazole-acetamide derivatives (7a–k)
were synthesized as potential therapeutic agents targeting Alzheimer's disease. The …
were synthesized as potential therapeutic agents targeting Alzheimer's disease. The …
Design, synthesis, and in vitro and in silico studies of 1, 3, 4-thiadiazole-thiazolidinone hybrids as carbonic anhydrase inhibitors
In this study, a series of 1, 3, 4-thiadiazole-thiazolidinone derivatives (7a–j) were
synthesized as carbonic anhydrase inhibitors. The in vitro carbonic anhydrase inhibitory …
synthesized as carbonic anhydrase inhibitors. The in vitro carbonic anhydrase inhibitory …
Design, synthesis, QSAR modelling and molecular dynamic simulations of N-tosyl-indole hybrid thiosemicarbazones as competitive tyrosinase inhibitors
Tyrosinase is an enzyme crucial for the progression of melanogenesis. Immoderate
production of melanin may be the cause of hyperpigmentation and darkening leading to skin …
production of melanin may be the cause of hyperpigmentation and darkening leading to skin …