Applications of genome‐scale metabolic reconstructions
The availability and utility of genome‐scale metabolic reconstructions have exploded since
the first genome‐scale reconstruction was published a decade ago. Reconstructions have …
the first genome‐scale reconstruction was published a decade ago. Reconstructions have …
Flux analysis and metabolomics for systematic metabolic engineering of microorganisms
Rational engineering of metabolism is important for bio-production using microorganisms.
Metabolic design based on in silico simulations and experimental validation of the metabolic …
Metabolic design based on in silico simulations and experimental validation of the metabolic …
From zero to hero—design-based systems metabolic engineering of Corynebacterium glutamicum for l-lysine production
J Becker, O Zelder, S Häfner, H Schröder… - Metabolic …, 2011 - Elsevier
Here, we describe the development of a genetically defined strain of l-lysine hyperproducing
Corynebacterium glutamicum by systems metabolic engineering of the wild type …
Corynebacterium glutamicum by systems metabolic engineering of the wild type …
Engineering Corynebacterium glutamicum for high-titer biosynthesis of hyaluronic acid
F Cheng, H Yu, G Stephanopoulos - Metabolic engineering, 2019 - Elsevier
Hyaluronic acid (HA) is a member of the glycosaminoglycan family and has been widely
used in the clinical, medical, cosmetic and food industries. In this study, we constructed a …
used in the clinical, medical, cosmetic and food industries. In this study, we constructed a …
A new genome-scale metabolic model of Corynebacterium glutamicum and its application
Background Corynebacterium glutamicum is an important platform organism for industrial
biotechnology to produce amino acids, organic acids, bioplastic monomers, and biofuels …
biotechnology to produce amino acids, organic acids, bioplastic monomers, and biofuels …
Genome-scale modeling for metabolic engineering
E Simeonidis, ND Price - Journal of Industrial Microbiology and …, 2015 - academic.oup.com
We focus on the application of constraint-based methodologies and, more specifically, flux
balance analysis in the field of metabolic engineering, and enumerate recent developments …
balance analysis in the field of metabolic engineering, and enumerate recent developments …
Advancing metabolic engineering through systems biology of industrial microorganisms
Z Dai, J Nielsen - Current opinion in biotechnology, 2015 - Elsevier
Highlights•Systems biology enables metabolic engineering design.•Metabolic engineering
targets can be identified by systems biology tools.•Integrating systems biology and metabolic …
targets can be identified by systems biology tools.•Integrating systems biology and metabolic …
Applications of genome-scale metabolic network model in metabolic engineering
Genome-scale metabolic network model (GEM) is a fundamental framework in systems
metabolic engineering. GEM is built upon extensive experimental data and literature …
metabolic engineering. GEM is built upon extensive experimental data and literature …
Improving putrescine production by Corynebacterium glutamicum by fine-tuning ornithine transcarbamoylase activity using a plasmid addiction system
J Schneider, D Eberhardt, VF Wendisch - Applied microbiology and …, 2012 - Springer
Corynebacterium glutamicum shows a great potential for the production of the polyamide
monomer putrescine (1, 4-diaminobutane). Previously, we constructed the putrescine …
monomer putrescine (1, 4-diaminobutane). Previously, we constructed the putrescine …
Metabolic flux analysis and pharmaceutical production
BA Boghigian, G Seth, R Kiss, BA Pfeifer - Metabolic engineering, 2010 - Elsevier
Rational engineering of biological systems is an inherently complex process due to their
evolved nature. Metabolic engineering emerged and developed over the past 20 years as a …
evolved nature. Metabolic engineering emerged and developed over the past 20 years as a …