Chaperonin mechanisms: Multiple and (mis) understood?
A Horovitz, TH Reingewertz, J Cuéllar… - Annual review of …, 2022 - annualreviews.org
The chaperonins are ubiquitous and essential nanomachines that assist in protein folding in
an ATP-driven manner. They consist of two back-to-back stacked oligomeric rings with …
an ATP-driven manner. They consist of two back-to-back stacked oligomeric rings with …
[HTML][HTML] The role of the molecular chaperone CCT in protein folding and mediation of cytoskeleton-associated processes: implications for cancer cell biology
J Vallin, J Grantham - Cell Stress and Chaperones, 2019 - Elsevier
The chaperonin-containing tailless complex polypeptide 1 (CCT) is required in vivo for the
folding of newly synthesized tubulin and actin proteins and is thus intrinsically connected to …
folding of newly synthesized tubulin and actin proteins and is thus intrinsically connected to …
The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions
S Tam, R Geller, C Spiess, J Frydman - Nature cell biology, 2006 - nature.com
Misfolding and aggregation of proteins containing expanded polyglutamine repeats underlie
Huntington's disease and other neurodegenerative disorders. Here, we show that the hetero …
Huntington's disease and other neurodegenerative disorders. Here, we show that the hetero …
TOR regulation of AGC kinases in yeast and mammals
E Jacinto, A Lorberg - Biochemical Journal, 2008 - portlandpress.com
The TOR (target of rapamycin), an atypical protein kinase, is evolutionarily conserved from
yeast to man. Pharmacological studies using rapamycin to inhibit TOR and yeast genetic …
yeast to man. Pharmacological studies using rapamycin to inhibit TOR and yeast genetic …
The interaction network of the chaperonin CCT
C Dekker, PC Stirling, EA McCormack, H Filmore… - The EMBO …, 2008 - embopress.org
The eukaryotic cytosolic chaperonin containing TCP‐1 (CCT) has an important function in
maintaining cellular homoeostasis by assisting the folding of many proteins, including the …
maintaining cellular homoeostasis by assisting the folding of many proteins, including the …
Heat shock proteins create a signature to predict the clinical outcome in breast cancer
M Klimczak, P Biecek, A Zylicz, M Zylicz - Scientific reports, 2019 - nature.com
Abstract Utilizing The Cancer Genome Atlas (TCGA) and KM plotter databases we identified
six heat shock proteins associated with survival of breast cancer patients. The survival …
six heat shock proteins associated with survival of breast cancer patients. The survival …
Ubiquitination screen using protein microarrays for comprehensive identification of Rsp5 substrates in yeast
Ubiquitin‐protein ligases (E3s) are responsible for target recognition and regulate stability,
localization or function of their substrates. However, the substrates of most E3 enzymes …
localization or function of their substrates. However, the substrates of most E3 enzymes …
[HTML][HTML] Activities of the chaperonin containing TCP-1 (CCT): implications for cell cycle progression and cytoskeletal organisation.
KI Brackley, J Grantham - Cell Stress and Chaperones, 2009 - Elsevier
The chaperonin containing TCP-1 (CCT) is required for the production of native actin and
tubulin and numerous other proteins, several of which are involved in cell cycle progression …
tubulin and numerous other proteins, several of which are involved in cell cycle progression …
Extracellular vesicles from neurosurgical aspirates identifies chaperonin containing TCP1 subunit 6A as a potential glioblastoma biomarker with prognostic …
Glioblastoma, WHO‐grade IV glioma, carries a dismal prognosis owing to its infiltrative
growth and limited treatment options. Glioblastoma‐derived extracellular vesicles (EVs; 30 …
growth and limited treatment options. Glioblastoma‐derived extracellular vesicles (EVs; 30 …
Structural and functional analysis of the role of the chaperonin CCT in mTOR complex assembly
The mechanistic target of rapamycin (mTOR) kinase forms two multi-protein signaling
complexes, mTORC1 and mTORC2, which are master regulators of cell growth, metabolism …
complexes, mTORC1 and mTORC2, which are master regulators of cell growth, metabolism …