The role of sex in the genomics of human complex traits
Nearly all human complex traits and disease phenotypes exhibit some degree of sex
differences, including differences in prevalence, age of onset, severity or disease …
differences, including differences in prevalence, age of onset, severity or disease …
The genetics of quantitative traits: challenges and prospects
TFC Mackay, EA Stone, JF Ayroles - Nature Reviews Genetics, 2009 - nature.com
A major challenge in current biology is to understand the genetic basis of variation for
quantitative traits. We review the principles of quantitative trait locus mapping and …
quantitative traits. We review the principles of quantitative trait locus mapping and …
The ABCs of depression: integrating affective, biological, and cognitive models to explain the emergence of the gender difference in depression.
In adulthood, twice as many women as men are depressed, a pattern that holds in most
nations. In childhood, girls are no more depressed than boys, but more girls than boys are …
nations. In childhood, girls are no more depressed than boys, but more girls than boys are …
The genetic architecture of quantitative traits
TFC Mackay - Annual review of genetics, 2001 - annualreviews.org
▪ Abstract Phenotypic variation for quantitative traits results from the segregation of alleles at
multiple quantitative trait loci (QTL) with effects that are sensitive to the genetic, sexual, and …
multiple quantitative trait loci (QTL) with effects that are sensitive to the genetic, sexual, and …
[图书][B] Sex, size and gender roles: evolutionary studies of sexual size dimorphism
Why do males and females frequently differ so markedly in body size and morphology? Sex,
Size, and Gender Roles is the first book to investigate the genetic, developmental, and …
Size, and Gender Roles is the first book to investigate the genetic, developmental, and …
Intralocus sexual conflict
R Bonduriansky, SF Chenoweth - Trends in ecology & evolution, 2009 - cell.com
Intralocus sexual conflict occurs when selection on a shared trait in one sex displaces the
other sex from its phenotypic optimum. It arises because many shared traits have a common …
other sex from its phenotypic optimum. It arises because many shared traits have a common …
Sexual selection, sexual conflict and the evolution of ageing and life span
1. Classic evolutionary models interpret ageing as a cost of reproduction, but evolutionary
research has thus far largely neglected the conceptual links between the evolution of ageing …
research has thus far largely neglected the conceptual links between the evolution of ageing …
Sex-and age-dependent genetics of longevity in a heterogeneous mouse population
DNA variants that modulate life span provide insight into determinants of health, disease,
and aging. Through analyses in the UM-HET3 mice of the Interventions Testing Program …
and aging. Through analyses in the UM-HET3 mice of the Interventions Testing Program …
[HTML][HTML] A new set of BXD recombinant inbred lines from advanced intercross populations in mice
Background Recombinant inbred (RI) strains are an important resource for mapping
complex traits in many species. While large RI panels are available for Arabidopsis, maize …
complex traits in many species. While large RI panels are available for Arabidopsis, maize …
Sex-specific genetic variance and the evolution of sexual dimorphism: a systematic review of cross-sex genetic correlations
The independent evolution of the sexes may often be constrained if male and female
homologous traits share a similar genetic architecture. Thus, cross-sex genetic covariance is …
homologous traits share a similar genetic architecture. Thus, cross-sex genetic covariance is …