Alveolar epithelial type II cells as drivers of lung fibrosis in idiopathic pulmonary fibrosis
Alveolar epithelial type II cells (AT2) are a heterogeneous population that have critical
secretory and regenerative roles in the alveolus to maintain lung homeostasis. However …
secretory and regenerative roles in the alveolus to maintain lung homeostasis. However …
Acetyl-CoA metabolism and histone acetylation in the regulation of aging and lifespan
PC Bradshaw - Antioxidants, 2021 - mdpi.com
Acetyl-CoA is a metabolite at the crossroads of central metabolism and the substrate of
histone acetyltransferases regulating gene expression. In many tissues fasting or lifespan …
histone acetyltransferases regulating gene expression. In many tissues fasting or lifespan …
Targeting histone deacetylases in idiopathic pulmonary fibrosis: a future therapeutic option
M Korfei, P Mahavadi, A Guenther - Cells, 2022 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with limited
therapeutic options, and there is a huge unmet need for new therapies. A growing body of …
therapeutic options, and there is a huge unmet need for new therapies. A growing body of …
Identifying collagen VI as a target of fibrotic diseases regulated by CREBBP/EP300
LM Williams, FE McCann, MA Cabrita… - Proceedings of the …, 2020 - National Acad Sciences
Fibrotic diseases remain a major cause of morbidity and mortality, yet there are few effective
therapies. The underlying pathology of all fibrotic conditions is the activity of myofibroblasts …
therapies. The underlying pathology of all fibrotic conditions is the activity of myofibroblasts …
The genetic and epigenetic footprint in idiopathic pulmonary fibrosis and familial pulmonary fibrosis: a state-of-the-art review
Idiopathic pulmonary fibrosis (IPF) is a rare disease of the lung with a largely unknown
etiology and a poor prognosis. Intriguingly, forms of familial pulmonary fibrosis (FPF) have …
etiology and a poor prognosis. Intriguingly, forms of familial pulmonary fibrosis (FPF) have …
EP300 as a molecular integrator of fibrotic transcriptional programs
K Rubio, A Molina-Herrera, A Pérez-González… - International Journal of …, 2023 - mdpi.com
Fibrosis is a condition characterized by the excessive accumulation of extracellular matrix
proteins in tissues, leading to organ dysfunction and failure. Recent studies have identified …
proteins in tissues, leading to organ dysfunction and failure. Recent studies have identified …
[HTML][HTML] Non-canonical integrin signaling activates EGFR and RAS-MAPK-ERK signaling in small cell lung cancer
Background: Small cell lung cancer (SCLC) is an extremely aggressive cancer type with a
patient median survival of 6-12 months. Epidermal growth factor (EGF) signaling plays an …
patient median survival of 6-12 months. Epidermal growth factor (EGF) signaling plays an …
Applications and approaches for three-dimensional precision-cut lung slices. Disease modeling and drug discovery
HN Alsafadi, FE Uhl, RH Pineda, KE Bailey… - American journal of …, 2020 - atsjournals.org
Chronic lung diseases (CLDs), such as chronic obstructive pulmonary disease, interstitial
lung disease, and lung cancer, are among the leading causes of morbidity globally and …
lung disease, and lung cancer, are among the leading causes of morbidity globally and …
Network pharmacology and molecular docking combined with widely targeted metabolomics to elucidate the potential compounds and targets of Euphorbia …
Y Liu, W Sun, N Shen, W Hao, H Xin, F Che… - Computers in Biology and …, 2023 - Elsevier
Background The whole herb of Euphorbia helioscopia has been traditionally used for
treating pulmonary tuberculosis, malaria, warts, lung cancer and bacillary dysentery for a …
treating pulmonary tuberculosis, malaria, warts, lung cancer and bacillary dysentery for a …
microRNA-186 in extracellular vesicles from bone marrow mesenchymal stem cells alleviates idiopathic pulmonary fibrosis via interaction with SOX4 and DKK1
J Zhou, Y Lin, X Kang, Z Liu, W Zhang, F Xu - Stem cell research & therapy, 2021 - Springer
Background Previous reports have identified that human bone marrow mesenchymal stem
cell-derived extracellular vesicles (BMSC-EVs) with their cargo microRNAs (miRNAs) are a …
cell-derived extracellular vesicles (BMSC-EVs) with their cargo microRNAs (miRNAs) are a …