Obesity has been described as a global epidemic and is a low-grade chronic inflammatory
disease that arises as a consequence of energy imbalance. Obesity increases the risk of …

Obesity affects more than 650 million individuals worldwide and is a well-established risk
factor for the development of hepatocellular carcinoma (HCC). Oxidative stress can be …

Obesity-related complications such as non-alcoholic fatty liver disease (NAFLD) and type 2
diabetes (T2D) are well-established risk factors for the development of hepatocellular …

The increased production of derivatives of molecular oxygen and nitrogen in the form of
reactive oxygen species (ROS) and reactive nitrogen species (RNS) lead to molecular …

Background Liver cancer is the second leading causes of cancer-related death globally.
Pyrroline-5-carboxylate reductase 1 (PYCR1) plays a critical role in metabolic profiles of …

Metabolic Syndrome is a multifactorial disease associated with increased risk of
cardiovascular disorders, type 2 diabetes mellitus, fatty liver disease, etc. Various stress …

The macrophage migration inhibitory factor (MIF) expressed in hepatocytes can limit
steatosis during obesity. Lipotoxicity in nonalcoholic fatty liver disease is mediated in part by …

Requirements for selenium and other antioxidant nutrients are increased in pro-oxidant and
pro-inflammatory conditions such as excess adiposity. Data concerning the association of …

Abstract The Activation-Induced Cell Death (AICD) is a stimulation-dependent form of
apoptosis used by the organism to shutdown T-cell response once the source of …

This review examines the latest epidemiological and molecular pathogenic findings of
metabolic-associated hepatocellular carcinoma (HCC). Its increasing prevalence is a …