Recent advances of controlled drug delivery using microfluidic platforms

ST Sanjay, W Zhou, M Dou, H Tavakoli, L Ma… - Advanced drug delivery …, 2018 - Elsevier
Conventional systematically-administered drugs distribute evenly throughout the body, get
degraded and excreted rapidly while crossing many biological barriers, leaving minimum …

Polymeric microneedles for controlled transdermal drug delivery

P Singh, A Carrier, Y Chen, S Lin, J Wang, S Cui… - Journal of controlled …, 2019 - Elsevier
Polymeric microneedle (MN) systems are interesting transdermal drug delivery systems
because of their controlled drug delivery, tunable properties, and ease of patient self …

Microneedle-mediated biomimetic cyclodextrin metal organic frameworks for active targeting and treatment of hypertrophic scars

T Wu, X Hou, J Li, H Ruan, L Pei, T Guo, Z Wang, T Ci… - Acs Nano, 2021 - ACS Publications
Due to the lack of a delivery system that actively targets hypertrophic scar fibroblasts (HSFs),
it is difficult to concentrate the effects of drugs on hypertrophic scars (HSs). We recently …

Biodegradable 3D printed polymer microneedles for transdermal drug delivery

MA Luzuriaga, DR Berry, JC Reagan, RA Smaldone… - Lab on a Chip, 2018 - pubs.rsc.org
Biodegradable polymer microneedle (MN) arrays are an emerging class of transdermal drug
delivery devices that promise a painless and sanitary alternative to syringes; however …

Recent advances in the design of polymeric microneedles for transdermal drug delivery and biosensing

M Wang, L Hu, C Xu - Lab on a Chip, 2017 - pubs.rsc.org
Microneedles are an efficient and minimally invasive approach to transdermal drug delivery
and extraction of skin interstitial fluid. Compared to solid microneedles made of silicon …

Recent development of drug delivery systems through microfluidics: From synthesis to evaluation

Z Ma, B Li, J Peng, D Gao - Pharmaceutics, 2022 - mdpi.com
Conventional drug administration usually faces the problems of degradation and rapid
excretion when crossing many biological barriers, leading to only a small amount of drugs …

Recent advances in microneedle platforms for transdermal drug delivery technologies

S Mdanda, P Ubanako, PPD Kondiah, P Kumar… - Polymers, 2021 - mdpi.com
In many clinical applications, the transdermal route is used as an alternative approach to
avoid the significant limitations associated with oral drug delivery. There is a long history for …

Development of a minimally invasive microneedle-based sensor for continuous monitoring of β-lactam antibiotic concentrations in vivo

SAN Gowers, DME Freeman, TM Rawson… - ACS …, 2019 - ACS Publications
Antimicrobial resistance poses a global threat to patient health. Improving the use and
effectiveness of antimicrobials is critical in addressing this issue. This includes optimizing …

Transdermal drug delivery system through polymeric microneedle: A recent update

M Azmana, S Mahmood, AR Hilles, UK Mandal… - Journal of Drug Delivery …, 2020 - Elsevier
As non-toxic, biodegradable, biocompatible materials, the polymeric microneedles have a
great significance in terms of delivering therapeutic drug molecules through the skin. They …

A review on solid microneedles for biomedical applications

N Tariq, MW Ashraf, S Tayyaba - Journal of Pharmaceutical Innovation, 2022 - Springer
Microelectromechanical system (MEMS)-based microneedles are an innovative way of drug
delivery that increases the permeability of the skin. It generates microscopic pores inside the …