Colorectal cancer (CRC) is among the most lethal and prevalent malignancies in the world
and was responsible for nearly 881,000 cancer-related deaths in 2018. Surgery and …

The ErbB receptor family, also known as the EGF receptor family or type I receptor family,
includes the epidermal growth factor (EGF) receptor (EGFR) or ErbB1/Her1, ErbB2/Her2 …

Both G protein-coupled receptors (GPCRs) and receptor-tyrosine kinases (RTKs) regulate
large signaling networks, control multiple cell functions and are implicated in many diseases …

Reelin is an extracellular matrix protein with various functions during development and in
the mature brain. It activates different signaling cascades in target cells, one of which is the …

Both the epidermal growth factor receptor (EGFR) and the insulin-like growth factor-1
receptor (IGF-1R) can contribute to tumor development and-progression through their effects …

Objective: Capillary malformation (CM) occurs sporadically and is associated with Sturge-
Weber syndrome. The somatic mosaic mutation in GNAQ (c. 548G> A, p. R183Q) is enriched …

Cancer immunotherapy focuses on inhibitors of checkpoint proteins, such as programmed
death ligand 1 (PD-L1). Unlike RAS-mutated lung cancers, EGFR mutant tumors have a …

Casitas B lineage lymphoma (c-Cbl) is a multifunctional protein with a ubiquitin E3 ligase
activity capable of degrading diverse sets of proteins. Although previous work had focused …

Phospholipase C (PLC) is an essential mediator of cellular signaling. PLC regulates multiple
cellular processes by generating bioactive molecules such as inositol-1, 4, 5-triphosphate …

Although endocrine therapy has dramatically improved the treatment of breast cancer
therapeutic resistance and tumour recurrence occurs, even in estrogen receptor (ER) …