Comprehensive review of targeted therapy for colorectal cancer
YH Xie, YX Chen, JY Fang - Signal transduction and targeted therapy, 2020 - nature.com
Colorectal cancer (CRC) is among the most lethal and prevalent malignancies in the world
and was responsible for nearly 881,000 cancer-related deaths in 2018. Surgery and …
and was responsible for nearly 881,000 cancer-related deaths in 2018. Surgery and …
ErbB receptors and cancer
Z Wang - ErbB receptor signaling: methods and protocols, 2017 - Springer
The ErbB receptor family, also known as the EGF receptor family or type I receptor family,
includes the epidermal growth factor (EGF) receptor (EGFR) or ErbB1/Her1, ErbB2/Her2 …
includes the epidermal growth factor (EGF) receptor (EGFR) or ErbB1/Her1, ErbB2/Her2 …
Transactivation of epidermal growth factor receptor by G protein-coupled receptors: recent progress, challenges and future research
Z Wang - International journal of molecular sciences, 2016 - mdpi.com
Both G protein-coupled receptors (GPCRs) and receptor-tyrosine kinases (RTKs) regulate
large signaling networks, control multiple cell functions and are implicated in many diseases …
large signaling networks, control multiple cell functions and are implicated in many diseases …
Reelin signals through phosphatidylinositol 3-kinase and Akt to control cortical development and through mTor to regulate dendritic growth
Y Jossin, AM Goffinet - Molecular and cellular biology, 2007 - Taylor & Francis
Reelin is an extracellular matrix protein with various functions during development and in
the mature brain. It activates different signaling cascades in target cells, one of which is the …
the mature brain. It activates different signaling cascades in target cells, one of which is the …
Crosstalk between epidermal growth factor receptor-and insulin-like growth factor-1 receptor signaling: implications for cancer therapy
S Oliveira, RM Schiffelers, G Storm… - Current cancer drug …, 2009 - ingentaconnect.com
Both the epidermal growth factor receptor (EGFR) and the insulin-like growth factor-1
receptor (IGF-1R) can contribute to tumor development and-progression through their effects …
receptor (IGF-1R) can contribute to tumor development and-progression through their effects …
Endothelial GNAQ p.R183Q Increases ANGPT2 (Angiopoietin-2) and Drives Formation of Enlarged Blood Vessels
L Huang, C Bichsel, AL Norris, J Thorpe… - … , and vascular biology, 2022 - Am Heart Assoc
Objective: Capillary malformation (CM) occurs sporadically and is associated with Sturge-
Weber syndrome. The somatic mosaic mutation in GNAQ (c. 548G> A, p. R183Q) is enriched …
Weber syndrome. The somatic mosaic mutation in GNAQ (c. 548G> A, p. R183Q) is enriched …
[HTML][HTML] PD-L1 recruits phospholipase C and enhances tumorigenicity of lung tumors harboring mutant forms of EGFR
S Ghosh, NB Nataraj, A Noronha, S Patkar, A Sekar… - Cell reports, 2021 - cell.com
Cancer immunotherapy focuses on inhibitors of checkpoint proteins, such as programmed
death ligand 1 (PD-L1). Unlike RAS-mutated lung cancers, EGFR mutant tumors have a …
death ligand 1 (PD-L1). Unlike RAS-mutated lung cancers, EGFR mutant tumors have a …
c-Cbl: an important regulator and a target in angiogenesis and tumorigenesis
CL Lyle, M Belghasem, VC Chitalia - Cells, 2019 - mdpi.com
Casitas B lineage lymphoma (c-Cbl) is a multifunctional protein with a ubiquitin E3 ligase
activity capable of degrading diverse sets of proteins. Although previous work had focused …
activity capable of degrading diverse sets of proteins. Although previous work had focused …
PLCγ1: potential arbitrator of cancer progression
HJ Jang, PG Suh, YJ Lee, KJ Shin, L Cocco… - Advances in biological …, 2018 - Elsevier
Phospholipase C (PLC) is an essential mediator of cellular signaling. PLC regulates multiple
cellular processes by generating bioactive molecules such as inositol-1, 4, 5-triphosphate …
cellular processes by generating bioactive molecules such as inositol-1, 4, 5-triphosphate …
Mechanisms of FGFR3 actions in endocrine resistant breast cancer
DC Tomlinson, MA Knowles… - International journal of …, 2012 - Wiley Online Library
Although endocrine therapy has dramatically improved the treatment of breast cancer
therapeutic resistance and tumour recurrence occurs, even in estrogen receptor (ER) …
therapeutic resistance and tumour recurrence occurs, even in estrogen receptor (ER) …