General anaesthesia is usually considered to safely induce a reversible brain state allowing
the performance of surgery under optimal conditions. An increasing number of clinical and …

There is a growing understanding that pathological genetic variation and environmental
insults during sensitive periods in brain development have long-term consequences on …

Background Few studies of how exposure of children to anesthesia may affect
neurodevelopment employ comprehensive neuropsychological assessments. This study …

Background Preclinical data suggest that general anaesthetics affect brain development.
There is mixed evidence from cohort studies that young children exposed to anaesthesia …

Despite lack of paediatric labelling, contributions to the literature on paediatric applications
of dexmedetomidine have increased over recent years. Dexmedetomidine possesses many …

Importance The results of preclinical studies suggest that anesthetic drugs administered to
neonatal animals cause widespread neuronal apoptosis and later neurocognitive …

Background Exposure of young animals to general anesthesia causes neurodegeneration
and lasting behavioral abnormalities; whether these findings translate to children remains …

Background Exposure of the fetal or neonatal non-human primate (NHP) brain to isoflurane
or ketamine for 5 h causes widespread apoptotic degeneration of neurones, and exposure …

Previously our laboratory has shown that ketamine exposure (24h of clinically relevant
anesthesia) causes significant increases in neuronal cell death in perinatal rhesus monkeys …

Alzheimer's disease (AD) is known as the most fatal chronic neurodegenerative disease in
adults along with progressive loss of memory and other cognitive function disorders. Cyclin …