With the accumulation of chemical and biological experimental data and the continuous
development of mathematical statistical algorithms, quantitative structure–activity …

The neuropeptides orexins and their G protein-coupled receptors, OX1 and OX2, were
discovered in 1998, and since then, their role has been investigated in many functions …

Opium is one of the world's oldest drugs, and its derivatives morphine and codeine are
among the most used clinical drugs to relieve severe pain. These prototypical opioids …

Experimental structure determination remains difficult for G protein-coupled receptors
(GPCRs). We propose a new hybrid protocol to construct GPCR structure models that …

The TSH receptor (TSHR) is a member of the glycoprotein hormone receptors, a subfamily of
family AG protein-coupled receptors. The TSHR is of great importance for the growth and …

Analysis of the literature involving computational modeling of diseases and drug design with
the aid of experimental spectroscopic techniques reveals that this specific combination of …

The autosomal dominant form of retinitis pigmentosa (adRP) is a blindness-causing
conformational disease largely linked to mutations of rhodopsin. Molecular simulations …

Aim: Both endothelin ET A receptor antagonists and angiotensin AT 1 receptor antagonists
lower blood pressure in hypertensive patients. A dual AT 1 and ET A receptor antagonist …

AG protein-coupled receptor (GPCR) functions not only as a monomer or homodimer but
also as a heterodimer with another GPCR. GPCR heterodimerization results in the …

The G protein-coupled receptor 84 (GPR84) is found in immune cells and its expression is
increased under inflammatory conditions. Activation of GPR84 by medium-chain fatty acids …