Free radicals have acquired growing importance in the fields of biology and medicine. They
are produced during many different endogenous and exogenous processes. Mitochondria …

Signaling by H2S is proposed to occur via persulfidation, a posttranslational modification of
cysteine residues (RSH) to persulfides (RSSH). Persulfidation provides a framework for …

Hydrogen sulfide (H 2 S) was once considered to have only toxic properties, until it was
discovered to be an endogenous signaling molecule. The effects of H 2 S are dose …

Abstract Significance: The thioredoxin (Trx) and glutathione (GSH) systems play important
roles in maintaining the redox balance in the brain, a tissue that is prone to oxidative stress …

Hydrogen sulfide (H 2 S) is a member of the growing family of gasotransmitters. Once
regarded as a noxious molecule predominantly present in the atmosphere, H 2 S is now …

The cysteine (Cys) proteome is a major component of the adaptive interface between the
genome and the exposome. The thiol moiety of Cys undergoes a range of biologic …

Cysteine residues in proteins are subject to diverse redox chemistry. Oxidation of cysteine to
S-nitrosocysteine, cysteine sulfenic and sulfinic acids, disulfides and persulfides are a few …

Hydrogen sulfide (H 2 S) was initially recognized as a toxic gas and its biological functions
in mammalian cells have been gradually discovered during the past decades. In the latest …

Intracellular redox imbalance is mainly caused by overproduction of reactive oxygen species
(ROS) or weakness of the natural antioxidant defense system. It is involved in the …

The expression of the reverse transsulfuration enzyme cystathionine-β-synthase (CBS) is
markedly increased in many forms of cancer, including colorectal, ovarian, lung, breast and …