Background Quercetin, a bioflavonoid abundant in grapefruit, onion, berries, etc., has vast
therapeutic potential, especially against Type 2 diabetes and its complications. Quercetin …

In the wake of the worldwide increase in type-2 diabetes, a major focus of research is
understanding the signaling pathways impacting this disease. Insulin signaling regulates …

The insulin signaling pathway is composed of a large number of molecules that positively or
negatively modulate insulin specific signal transduction following its binding to the cognate …

Objective Glucose and lipid metabolism disorders are a major risk factor for type II diabetes
and cardiovascular diseases. Evidence has indicated that the interplay between the liver …

Precise control of the balance between protein phosphorylation, catalyzed by protein
kinases, and protein dephosphorylation, catalyzed by protein phosphatases, is essential for …

In the decade since their discovery, the PH domain leucine-rich repeat protein
phosphatases (PHLPP) have emerged as critical regulators of cellular homeostasis, and …

The circadian rhythm regulates biological processes that occur within 24 h in living
organisms. It plays a fundamental role in maintaining biological functions and responds to …

Insulin signaling plays a physiological role in traditional insulin target tissues controlling
glucose homeostasis as well as in pancreatic β-cells and in the endothelium. Insulin …

The recently discovered pleckstrin homology (PH) domain leucine‐rich repeat protein
phosphatase (PHLPP) family is emerging as a central component in suppressing cell …

Hepatic and systemic insulin resistance form the core of metabolic syndrome which is also
associated with cardiovascular abnormalities, inflammation, and dyslipidemia. Skeletal …