Polymer encapsulation of ruthenium complexes for biological and medicinal applications

E Villemin, YC Ong, CM Thomas… - Nature Reviews Chemistry, 2019 - nature.com
Some Ru complexes have extremely promising anticancer or antibacterial properties, but
the poor H2O solubility and/or low stability of many Ru complexes in aqueous solution under …

Machine learning for faster and smarter fluorescence lifetime imaging microscopy

V Mannam, Y Zhang, X Yuan, C Ravasio… - Journal of Physics …, 2020 - iopscience.iop.org
Fluorescence lifetime imaging microscopy (FLIM) is a powerful technique in biomedical
research that uses the fluorophore decay rate to provide additional contrast in fluorescence …

Polymeric encapsulation of a Ru (II)-based photosensitizer for folate-targeted photodynamic therapy of drug resistant cancers

J Karges, M Tharaud, G Gasser - Journal of Medicinal Chemistry, 2021 - ACS Publications
The currently used photodynamic therapy (PDT) photosensitizers (PSs) are generally
associated with a poor cancer cell selectivity, which is responsible for some undesirable …

Two-photon absorbing phosphorescent metalloporphyrins: effects of π-extension and peripheral substitution

TV Esipova, HJ Rivera-Jacquez, B Weber… - Journal of the …, 2016 - ACS Publications
The ability to form triplet excited states upon two-photon excitation is important for several
applications of metalloporphyrins, including two-photon phosphorescence lifetime …

Nanomaterials for reactive oxygen species detection and monitoring in biological environments

GT Huynh, V Kesarwani, JA Walker, JE Frith… - Frontiers in …, 2021 - frontiersin.org
Reactive oxygen species (ROS) and dissolved oxygen play key roles across many
biological processes, and fluorescent stains and dyes are the primary tools used to quantify …

Heteronuclear Ir (III)–Ln (III) luminescent complexes: Small-molecule probes for dual modal imaging and oxygen sensing

A Jana, BJ Crowston, JR Shewring… - Inorganic …, 2016 - ACS Publications
Luminescent, mixed metal d–f complexes have the potential to be used for dual (magnetic
resonance imaging (MRI) and luminescence) in vivo imaging. Here, we present dinuclear …

Multimodal probes: superresolution and transmission electron microscopy imaging of mitochondria, and oxygen mapping of cells, using small-molecule Ir (III) …

JR Shewring, AJ Cankut, LK McKenzie… - Inorganic …, 2017 - ACS Publications
We describe an Ir (III)-based small-molecule, multimodal probe for use in both light and
electron microscopy. The direct correlation of data between light-and electron-microscopy …

Synthesis, Characterization, and Biological Evaluation of the Polymeric Encapsulation of a Ruthenium (II) Polypyridine Complex with Pluronic F‐127/Poloxamer‐407 …

J Karges, H Chao, G Gasser - European Journal of Inorganic …, 2020 - Wiley Online Library
The therapy of cancer remains a major challenge for modern medicine. Complementary to
classical treatments, the use of photodynamic therapy (PDT) has received increasing …

Investigation of signal-to-noise ratio in frequency-domain multiphoton fluorescence lifetime imaging microscopy

Y Zhang, AA Khan, GD Vigil, SS Howard - JOSA A, 2016 - opg.optica.org
Multiphoton microscopy (MPM) combined with fluorescence lifetime imaging microscopy
(FLIM) has enabled three-dimensional quantitative molecular microscopy in vivo. The signal …

Encapsulation of Cu (II) Terpyridine Complexes into Polymeric Nanoparticles for Enhanced Anticancer Therapy

N Montesdeoca, K Ni, J Karges - Chemistry–A European …, 2024 - Wiley Online Library
Cancer is one of the deadliest diseases worldwide. One of the most commonly applied
therapeutic techniques to combat this disease is chemotherapy. Despite its success, the …