Cyclin D1, and to a lesser extent the other D-type cyclins, is frequently deregulated in cancer
and is a biomarker of cancer phenotype and disease progression. The ability of these …

Increases in cytosolic free Ca2+ ([Ca2+] i) represent a ubiquitous signalling mechanism that
controls a variety of cellular processes, including proliferation, metabolism and gene …

Comprehensive gene expression patterns generated from cDNA microarrays were
correlated with detailed clinico-pathological characteristics and clinical outcome in an …

Breast cancer is not a single disease, but is instead a collection of diseases that have
distinct histopathological features, genetic and genomic variability, and diverse prognostic …

The tumour stroma is believed to contribute to some of the most malignant characteristics of
epithelial tumours. However, signalling between stromal and tumour cells is complex and …

Differential gene expression following early renal ischemia/reperfusion. Background Acute
renal failure from ischemia/reperfusion injury is associated with tubule cell apoptosis, the …

Metastatic spread of cancer cells is the main cause of death of breast cancer patients, and
elucidation of the molecular mechanisms underlying this process is a major focus in cancer …

Abstract Learning Objectives After completing this course, the reader will be able to:
Differentiate between the actions of oncogenes and tumor suppressor genes in the …

Breast cancer is a genetically and clinically heterogeneous disease, and the contributions of
different target cells and different oncogenic mutations to this heterogeneity are not well …

We developed stromal-and epithelial-specific cre-transgenic mice to directly visualize
epithelial-mesenchymal transition (EMT) during cancer progression in vivo. Using three …