Cellular differentiation is, by definition, epigenetic. Genome-wide profiling of pluripotent cells
and differentiated cells suggests global chromatin remodelling during differentiation, which …

Macromolecular assemblies that regulate chromatin structure using the energy of ATP
hydrolysis have critical roles in development, cancer, and stem cell biology. The ATPases of …

Post-translational modifications of p53 are critical in modulating its tumor suppressive
functions. Ubiquitylation, for example, plays a major role in dictating p53 stability, subcellular …

Pluripotent stem cells can be derived from embryos or induced from adult cells by
reprogramming. They are unique among stem cells in that they can give rise to all cell types …

In metazoans, cells depend on extracellular growth factors for energy homeostasis. We
found that glycogen synthase kinase-3 (GSK3), when deinhibited by default in cells deprived …

Research over the past three decades has firmly established lysine acetyltransferases
(KATs) as central players in regulating transcription. Recent advances in genomic …

Nucleosomal acetyltransferase of H4 (NuA4) is an essential transcriptional coactivator in
eukaryotes, but remains poorly characterized in plants. Here, we describe Arabidopsis …

Histone acetylation has been recognized as an important post‐translational modification of
core nucleosomal histones that changes access to the chromatin to allow gene transcription …

Cells are constantly exposed to genotoxic events that can damage DNA. To counter this,
cells have evolved a series of highly conserved DNA repair pathways to maintain genomic …

Summary mTORC1 and GSK3 play critical roles in early stages of (macro) autophagy, but
how they regulate late steps of autophagy remains poorly understood. Here we show that …