Background Few studies have assessed participant safety in human challenge trials (HCTs).
Key questions regarding HCTs include how risky such trials have been, how often adverse …

Enteric infectious diseases account for more than a billion disease episodes yearly
worldwide resulting in approximately 2 million deaths, with children under 5 years old and …

In Asia, there are an estimated 12 million annual cases of enteric fever, a potentially fatal
systemic bacterial infection caused by Salmonella enterica serovars Typhi (STy) and …

Tuberculosis (TB) is a prevalent disease causing an estimated 1.6 million deaths and 10.6
million new cases annually. Discriminating TB disease from differential diagnoses can be …

Background Enteric fever caused by Salmonella enterica Typhi and Salmonella Paratyphi A
is an important public health problem, especially in low-income and middle-income …

Background Typhoid fever causes substantial global mortality, with almost half occurring in
India. New typhoid vaccines are highly effective and recommended by the World Health …

Enteric fever is caused by Salmonella enterica serovar Typhi, Salmonella enterica serovar
Paratyphi A, B, and C. While S. Typhi remains the primary causative agent of enteric fever, S …

Enteric fever, caused by oral infection with typhoidal Salmonella serovars, presents as a non-
specific febrile illness preceded by an incubation period of 5 days or more. The enteric fever …

Infections with Salmonella enterica serovars Typhi and Paratyphi A cause an estimated 14
million cases of enteric fever annually. Here, the controlled nature of challenge studies is …

Introduction This is the first efficacy study of an oral live attenuated vaccine against
Salmonella Paratyphi A using a human challenge model of paratyphoid infection. S …