Skeletal muscle contains a designated population of adult stem cells, called satellite cells,
which are generally quiescent. In homeostasis, satellite cells proliferate only sporadically …

Skeletal muscle represents the largest body-composition component in humans. In addition
to its primary function in the maintenance of upright posture and the production of …

Skeletal muscle is the largest tissue in the body and loss of its function or its regenerative
properties results in debilitating musculoskeletal disorders. Understanding the mechanisms …

Skeletal muscle requires a highly orchestrated coordination between multiple cell types and
their microenvironment to exert its function and to maintain its homeostasis and regenerative …

Progress toward finding a cure for muscle diseases has been slow because of the absence
of relevant cellular models and the lack of a reliable source of muscle progenitors for …

Age-related changes in the niche have long been postulated to impair the function of
somatic stem cells. Here we demonstrate that the aged stem cell niche in skeletal muscle …

Stem cell niches are composed of dynamic microenvironments that support stem cells over a
lifetime. The emerging niche is distinct from the adult because its main role is to support the …

Many adult tissues contain resident stem cells, such as the Pax7+ satellite cells within
skeletal muscle, that regenerate parenchymal elements following damage. Tissue-resident …

Normal homeostatic functions of adult stem cells have rhythmic daily oscillations that are
believed to become arrhythmic during aging. Unexpectedly, we find that aged mice remain …

The developmental trajectory of human skeletal myogenesis and the transition between
progenitor and stem cell states are unclear. We used single-cell RNA sequencing to profile …