Ischemic heart disease still represents a large burden on individuals and health care
resources worldwide. By conventions, it is equated with atherosclerotic plaque due to flow …

Simple Summary The progressive nature of type 2 diabetes mellitus (T2DM) leads to micro-
and macro-vascular complications, including renal and cardiovascular disease. These …

Heart failure is a complex syndrome responsible for high rates of death and hospitalization.
Ischemic heart disease is one of the most frequent causes of heart failure and it is normally …

Chronic heart failure (CHF) is a complex syndrome that results from structural and functional
disturbances that affect the ability of the heart to supply oxygen to tissues. It largely affects …

Advanced heart failure (AdHF) represents a challenging aspect of heart failure patients.
Because of worsening clinical symptoms, high rates of re-hospitalization and mortality, AdHF …

Myocardial ischemia constitutes one of the most important pathophysiological features in
hypertrophic cardiomyopathy. Chronic and recurrent myocardial ischemia leads to fibrosis …

Circular RNAs (circRNAs) are involved in the development and progression of diabetic
cardiomyopathy (DCM). However, the specific function and underlying mechanism of …

Sodium glucose cotransporter 2 (SGLT2) inhibitors and glucagon-like-peptide-1 receptor
(GLP-1-R) agonists are novel therapeutic agents used for the management of type 2 …

The inhibition of mammalian target of rapamycin (mTOR) with rapamycin (RAPA) provides
protection against myocardial ischemia/reperfusion (I/R) injury in diabetes. Since …

Heart failure with preserved ejection fraction (HFpEF) is a complex clinical syndrome
responsible for high mortality and morbidity rates. It has an ever growing social and …